Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | NOS1 | P29475 | 3/20 | 0.53 |
| ▸ | MAOA | P21397 | 2/20 | 0.52 |
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 2/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3863134 | 0.98 | MAOA (0.53) | ALDH1A1TSHRNOS1MAOAMAOB | |
| Hydrochloric Acid SCHEMBL5913208 | 0.98 | MAOA (0.53) | ALDH1A1TSHRNOS1MAOAMAOB | |
| SCHEMBL989636 | 0.84 | ALDH1A1 (0.67) | ALDH1A1TSHRNOS1HTR7CHRNB2 | |
| SCHEMBL28223911 | 0.83 | HSD11B1 (0.49) | ALDH1A1NOS1MAOAMAOBCYP19A1 | |
| SCHEMBL13185158 | 0.83 | MAOB (0.48) | ALDH1A1NOS1MAOAMAOBCYP19A1 | |
| SCHEMBL374305 | 0.83 | ALDH1A1 (0.49) | ALDH1A1TSHRNOS1MAOAMAOB | |
| SCHEMBL3146615 | 0.82 | CHRNB2 (0.50) | MAOAMAOBCYP19A1HSD11B1CYP3A4 | |
| SCHEMBL13085739 | 0.82 | ALDH1A1 (0.43) | ALDH1A1TSHRNOS1MAOAMAOB | |
| SCHEMBL6675561 | 0.82 | MAOB (0.57) | ALDH1A1TSHRMAOAMAOBCYP19A1 | |
| SCHEMBL529408 | 0.79 | TAAR1 (0.61) | NOS1MAOAMAOBCYP19A1HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 337 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117209485-A | Pyrimidine skeleton compound with anti-tumor activity and preparation method and application thereof | 四川大学华西医院 | 2023-12-12 | — | — | CN | claimed |
| EP-2188289-A2 | (7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-PIPERAZINES AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND INFLAMMATION | Lexicon Pharmaceuticals, Inc. (US) | 2010-05-26 | — | — | EP | claimed |
| WO-2009021169-A2 | (7H-PYRR0L0 [2, 3-D] PYRIMIDIN-4-YL) -PIPERAZINES AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND INFLAMMATION | LEXICON PHARMACEUTICALS, INC. (US) | 2009-02-12 | — | — | WO | claimed |
| US-12534474-B2 | Dihydrofuropyridine derivatives as rho-kinase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2026-01-27 | — | — | US | disclosed |
| EP-4387963-B1 | PHENYL- AND PYRIDOPYRAZOLE DERIVATIVES AS INHIBITORS OF DDR1 | REDX PHARMA LTD (GB) | 2025-12-24 | — | — | EP | disclosed |
| EP-4263546-B1 | DIHYDROFUROPYRIDINE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARM SPA (IT) | 2025-07-02 | — | — | EP | disclosed |
| EP-4263547-B1 | DIHYDROFUROPYRIDINE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARM SPA (IT) | 2025-07-02 | — | — | EP | disclosed |
| WO-2025133613-A1 | COMPOUNDS COMPRISING A NAPHTHYRIDINE OR PYRIDO-PYRIMIDINE CORE AND A (HETERO)AROMATIC-AMINO SUBSTITUENT | Tay Therapeutics Limited (GB) | 2025-06-26 | — | — | WO | disclosed |
| US-20250186447-A1 | WEE1 KINASE INHIBITORS AND METHODS OF TREATING CANCER USING THE SAME | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2025-06-12 | — | — | US | disclosed |
| EP-4522618-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES COMPOUNDS AS HPK1 INHIBITORS | Merck Patent GmbH (DE) | 2025-03-19 | — | — | EP | disclosed |
| EP-3617213-B1 | THIENO[3,2-D]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES | HANMI PHARMACEUTICAL CO LTD (KR) | 2025-02-19 | — | — | EP | disclosed |
| EP-0094727-A2 | Substituted heterocyclyl phenylformamidines, processes for their preparation and their pharmaceutical use | ISTITUTO DE ANGELI S.p.A. (IT) | 1983-11-23 | — | — | EP | disclosed |
| EP-0074589-A2 | Triazine dyes, their preparation and their use | BAYER AG (DE) | 1983-03-23 | — | — | EP | disclosed |
| EP-0072508-A2 | Pyrazolone derivatives, their preparation and use as coupling components | BAYER AG (DE) | 1983-02-23 | — | — | EP | disclosed |
| EP-0012294-B1 | QUATERNARY REACTIVE COMPOUNDS, THEIR PREPARATION AND THEIR APPLICATION TO INCREASE THE AFFINITY OF ANIONIC DYESTUFFS TO FIBRES CONTAINING NITROGEN OR HYDROXYL GROUPS | BAYER AG (DE) | 1983-02-16 | — | — | EP | disclosed |
| EP-0057245-A2 | Cationic triazine dyestuffs, their preparation and their use | BAYER AG (DE) | 1982-08-11 | — | — | EP | disclosed |
| EP-0054616-A2 | Cationic triazine dyestuffs, their preparation and process of dying | BAYER AG (DE) | 1982-06-30 | — | — | EP | disclosed |
| US-4281124-A | Reactive quaternary compounds, their preparation and their use for increasing the affinity of anionic dyestuffs for fibres which contain nitrogen or hydroxyl groups | BAYER AKTIENGESELLSCHAFT (DE) | 1981-07-28 | — | — | US | disclosed |
| EP-0015365-A1 | Quaternary reactive compounds, their preparation and their use in enhancing the affinity of anionic dyestuffs | BAYER AG (DE) | 1980-09-17 | — | — | EP | disclosed |
| EP-0012294-A1 | Quaternary reactive compounds, their preparation and their application to increase the affinity of anionic dyestuffs to fibres containing nitrogen or hydroxyl groups | BAYER AG (DE) | 1980-06-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12534474-B2 | Dihydrofuropyridine derivatives as rho-kinase inhibitors | ROCK1, RHOC, ROCK2 | ALDH1A1 1959/4885TSHR 3258/4885NOS1 324/4885 |
| US-20250186447-A1 | WEE1 KINASE INHIBITORS AND METHODS OF TREATING CANCER USING THE SAME | WEE1, WEE2, NME1 | ALDH1A1 3933/4885TSHR 3859/4885NOS1 3048/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.