Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 14/20 | 0.77 |
| ▸ | DRD4 | P21917 | 14/20 | 0.77 |
| ▸ | HTR2A | P28223 | 2/20 | 0.58 |
| ▸ | HTR7 | P34969 | 1/20 | 0.58 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.57 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.57 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.57 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.57 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.57 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.57 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.57 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.57 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.57 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.57 |
| ▸ | HPGDS | O60760 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1366085 | 0.89 | CCR3 (0.61) | DRD2DRD4MCHR1SIGMAR1SLC6A12 | |
| SCHEMBL1364288 | 0.88 | CCR3 (0.63) | DRD2DRD4MCHR1SIGMAR1SLC6A12 | |
| SCHEMBL8705985 | 0.87 | DRD2 (1.00) | DRD2DRD4HTR2AHTR7MCHR1 | |
| SCHEMBL1367099 | 0.84 | DRD4 (0.61) | DRD2DRD4HTR2AMCHR1SIGMAR1 | |
| SCHEMBL13610005 | 0.84 | HPGDS (0.75) | DRD2DRD4MCHR1SIGMAR1SLC6A12 | |
| SCHEMBL1366534 | 0.83 | PRKAA2 (0.75) | DRD2DRD4MCHR1SIGMAR1SLC6A12 | |
| SCHEMBL1366021 | 0.83 | DRD2 (0.52) | DRD2DRD4HTR7HPGDS | |
| SCHEMBL1367102 | 0.83 | ALDH1A1 (0.59) | DRD2DRD4HTR7MCHR1SIGMAR1 | |
| SCHEMBL8705987 | 0.82 | CCR3 (0.75) | DRD2DRD4HTR2ASIGMAR1 | |
| SCHEMBL1365939 | 0.82 | HPGDS (0.61) | DRD2DRD4HTR7MCHR1PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067589-B2 | Heterocyclic compounds useful in treating diseases and conditions | PFIZER INC (US) | 2011-11-29 | — | — | US | disclosed |
| US-20090281125-A1 | Heterocyclic Compounds Useful in Treating Diseases and Conditions | BLAKE TANISHA D | 2009-11-12 | — | — | US | disclosed |
| US-7582643-B2 | Heterocyclic compounds useful in treating diseases and conditions | PFIZER INC (US) | 2009-09-01 | — | — | US | disclosed |
| US-20080207651-A1 | Heterocyclic compounds useful in treating diseases and conditions | BLAKE TANISHA D | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281125-A1 | Heterocyclic Compounds Useful in Treating Diseases and Conditions | CYP11B2, CYP11B1, LTC4S | DRD2 4108/4885DRD4 4232/4885HTR2A 1671/4885 |
| US-20080207651-A1 | Heterocyclic compounds useful in treating diseases and conditions | CYP11B2, CYP11B1, LTC4S | DRD2 4108/4885DRD4 4232/4885HTR2A 1671/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.