Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 2/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7606111 | 0.92 | KMT2A (0.47) | TP53LMNAKMT2APGRPOLB | |
| SCHEMBL7602899 | 0.92 | LMNA (0.50) | TP53LMNAKMT2APGRPOLB | |
| SCHEMBL1081746 | 0.86 | BDKRB2 (0.40) | LMNAKMT2APDE4APDE4BPDE4C | |
| SCHEMBL7604032 | 0.84 | PGR (0.42) | TP53LMNAKMT2APGRPDE4A | |
| SCHEMBL7601937 | 0.82 | BDKRB2 (0.37) | TP53LMNAKMT2APGRHRH3 | |
| SCHEMBL7601099 | 0.81 | KMT2A (0.45) | TP53LMNAKMT2APGRPOLB | |
| SCHEMBL7605776 | 0.81 | KMT2A (0.47) | TP53LMNAKMT2APGRPOLB | |
| SCHEMBL7604168 | 0.81 | KMT2A (0.48) | TP53LMNAKMT2APGRPOLB | |
| SCHEMBL7904520 | 0.80 | KMT2A (0.46) | TP53LMNAKMT2APGRPOLB | |
| SCHEMBL1177753 | 0.80 | MAOB (0.40) | TP53PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009127338-A1 | OXO-HETEROCYCLIC SUBSTITUTED CARBOXYLIC ACID DERIVATES AND THE USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-10-22 | — | — | WO | disclosed |