Sugi Predict

Sugi Predict / Compounds / SCHEMBL1366438

SCHEMBL1366438

SCHEMBL1366438

CC(=O)c1ccn(S(=O)(=O)c2ccccc2)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PKM P14618 1/20 1.00
▸ ALDH1A1 P00352 4/20 0.72
▸ TUBB4A P04350 2/20 0.58
▸ TUBB P07437 2/20 0.58
▸ TUBA3C P0DPH7 2/20 0.58
▸ TUBA1B P68363 2/20 0.58
▸ TUBA4A P68366 2/20 0.58
▸ TUBB4B P68371 2/20 0.58
▸ TUBB3 Q13509 2/20 0.58
▸ TUBB2A Q13885 2/20 0.58
▸ TUBB8 Q3ZCM7 2/20 0.58
▸ TUBA3E Q6PEY2 2/20 0.58
▸ TUBA1A Q71U36 2/20 0.58
▸ TUBA1C Q9BQE3 2/20 0.58
▸ TUBB6 Q9BUF5 2/20 0.58
▸ TUBB2B Q9BVA1 2/20 0.58
▸ TUBB1 Q9H4B7 2/20 0.58
▸ HDAC6 Q9UBN7 1/20 0.55
▸ KMT2A Q03164 3/20 0.54
▸ MEN1 O00255 2/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4513102 0.85 ALDH1A1 (0.75) PKMALDH1A1TUBB4ATUBBTUBA3C
SCHEMBL4780674 0.83 PKM (0.70) PKMALDH1A1TUBB4ATUBBTUBA3C
SCHEMBL4781263 0.83 PKM (0.70) PKMALDH1A1TUBB4ATUBBTUBA3C
SCHEMBL14278743 0.81 PKM (0.68) PKMALDH1A1TUBB4ATUBBTUBA3C
SCHEMBL9590857 0.81 PKM (0.68) PKMALDH1A1TUBB4ATUBBTUBA3C
SCHEMBL2717445 0.80 PKM (0.67) PKMALDH1A1TUBB4ATUBBTUBA3C
SCHEMBL28762225 0.80 PKM (0.66) PKMALDH1A1TUBB4ATUBBTUBA3C
SCHEMBL1516211 0.78 PKM (0.64) PKMALDH1A1TUBB4ATUBBTUBA3C
SCHEMBL27674625 0.78 PKM (0.63) PKMALDH1A1TUBB4ATUBBTUBA3C
SCHEMBL27744199 0.78 PKM (0.63) PKMALDH1A1TUBB4ATUBBTUBA3C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100221647-A1 PYRROLE CONTAINING PHOTOCONDUCTORS XEROX CORPORATION (US) 2010-09-02 — — US claimed
US-20220204485-A1 STABILIZATION OF AMYLOIDOGENIC IMMUNOGLOBULIN LIGHT CHAINS THE SCRIPPS RESEARCH INSTITUTE 2022-06-30 — — US disclosed
US-10144746-B2 Bridged bicyclic kallikrein inhibitors GLOBAL BLOOD THERAPEUTICS, INC. (US) 2018-12-04 — — US disclosed
US-20180194780-A1 BRIDGED BICYCLIC KALLIKREIN INHIBITORS GLOBAL BLOOD THERAPEUTICS, INC. 2018-07-12 — — US disclosed
US-9815853-B2 Bridged bicyclic kallikrein inhibitors GLOBAL BLOOD THERAPEUTICS, INC. (US) 2017-11-14 — — US disclosed
WO-2016201052-A1 BRIDGED BICYCLIC KALLIKREIN INHIBITORS GLOBAL BLOOD THERAPEUTICS, INC. (US) 2016-12-15 — — WO disclosed
US-20160362427-A1 BRIDGED BICYCLIC KALLIKREIN INHIBITORS GLOBAL BLOOD THERAPEUTICS, INC. 2016-12-15 — — US disclosed
US-8067138-B2 Pyrrole containing photoconductors XEROX CORPORATION (US) 2011-11-29 — — US disclosed
US-8067138-B2 Pyrrole containing photoconductors XEROX CORPORATION (US) 2011-11-29 — — US disclosed
US-8067138-B2 Pyrrole containing photoconductors XEROX CORPORATION (US) 2011-11-29 — — US disclosed
US-6645956-B1 1-(5-(4-fluorobenzyl)furan-2-yl)-3-hydroxy-3-(1H-1,2,4-triazol-3 -yl)-propenone; viricides; AIDS treatment SHIONOGI & CO., LTD. (JP) 2003-11-11 — — US disclosed
US-6620841-B1 Furan or benzofuran derivatives substituted with triazole; acquired immunodeficiency syndrome (AIDS) SHIONOGI & CO., LTD. (JP) 2003-09-16 — — US disclosed
US-6498165-B1 PYRIMIDINE COMPOUNDS; PROPHYLAXIS AND TREATMENT OF SUCH AS IMMUNE DISEASES, HYPERPROLIFERATIVE DISORDERS, CANCER, ANGIOGENSIS, ATHEROSCELEROSIS, GRAFT REJECTION, RHEUMATOID ARTHRITIS, PSORIASIS MERCK & CO., INC. 2002-12-24 — — US disclosed
EP-1206265-A4 SRC KINASE INHIBITOR COMPOUNDS MERCK & CO INC (US) 2002-08-07 — — EP disclosed
EP-1206265-A1 SRC KINASE INHIBITOR COMPOUNDS Merck & Co., Inc. (US) 2002-05-22 — — EP disclosed
CN-1335834-A Aromatic heterocyclic compounds having HIV integrase inhibitory activity SHIONOGI & CO (JP) 2002-02-13 — — CN disclosed
EP-1142872-A1 AROMATIC HETEROCYCLE COMPOUNDS HAVING HIV INTEGRASE INHIBITING ACTIVITIES SHIONOGI & CO., LTD. (JP) 2001-10-10 — — EP disclosed
WO-2001000213-A1 SRC KINASE INHIBITOR COMPOUNDS MERCK & CO., INC. (US) 2001-01-04 — — WO disclosed
US-5210193-A Bactericide AMERICAN CYANAMID COMPANY (US) 1993-05-11 — — US disclosed
US-4940710-A 7-(substituted)piperazinyl-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids AMERICAN CYANAMID COMPANY (US) 1990-07-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10144746-B2 Bridged bicyclic kallikrein inhibitors KLKB1, KLK1, KLK2 PKM 189/4885ALDH1A1 2650/4885TUBB4A 2886/4885
US-20160362427-A1 BRIDGED BICYCLIC KALLIKREIN INHIBITORS KLKB1, KLK1, KLK2 PKM 189/4885ALDH1A1 2650/4885TUBB4A 2886/4885
US-20180194780-A1 BRIDGED BICYCLIC KALLIKREIN INHIBITORS KLKB1, KLK1, KLK2 PKM 189/4885ALDH1A1 2650/4885TUBB4A 2886/4885
US-20220204485-A1 STABILIZATION OF AMYLOIDOGENIC IMMUNOGLOBULIN LIGHT CHAINS TTR, MAP1LC3B, SAAL1 PKM 3465/4885ALDH1A1 2072/4885TUBB4A 2010/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.