Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.40 |
| ▸ | MAPT | P10636 | 11/20 | 0.40 |
| ▸ | HPGD | P15428 | 8/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | ATM | Q13315 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13666120 | 0.67 | LOX (0.34) | ALDH1A1MAPTHPGDL3MBTL1MEN1 | |
| SCHEMBL29059899 | 0.63 | HSD11B1 (0.40) | HSD11B1ALDH1A1MAPTHPGDL3MBTL1 | |
| SCHEMBL16158830 | 0.62 | MEN1 (0.57) | ALDH1A1MAPTHPGDL3MBTL1MEN1 | |
| SCHEMBL4296224 | 0.62 | POLB (0.45) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL2892140 | 0.62 | LMNA (0.59) | ALDH1A1MAPTHPGDMEN1KMT2A | |
| SCHEMBL9421729 | 0.62 | LMNA (0.59) | ALDH1A1MAPTHPGDMEN1KMT2A | |
| Methyl Alcohol SCHEMBL28191829 | 0.59 | SMN1; SMN2 (0.54) | ALDH1A1MAPTMEN1KMT2ATDP1 | |
| SCHEMBL10337830 | 0.58 | BCL2L1 (0.57) | ALDH1A1MAPTHPGDMEN1KMT2A | |
| SCHEMBL21517157 | 0.58 | ALDH1A1 (0.48) | ALDH1A1MAPTMEN1KMT2ATDP1 | |
| SCHEMBL17193970 | 0.58 | MAPT (0.54) | ALDH1A1MAPTHPGDL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090270361-A1 | Substituted pyrazole derivatives and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270361-A1 | Substituted pyrazole derivatives and use thereof | CBR3, CBR1, NOX5 | HSD11B1 802/4885ALDH1A1 1105/4885MAPT 3590/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.