Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.34 |
| ▸ | APLNR | P35414 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1366943 | 0.89 | ALDH1A1 (0.37) | ALDH1A1POLBTP53MAPTSMN1; SMN2 | |
| SCHEMBL1367091 | 0.89 | S1PR3 (0.43) | — | |
| SCHEMBL1367487 | 0.87 | ALDH1A1 (0.36) | ALDH1A1POLBTP53MAPTSMN1; SMN2 | |
| SCHEMBL1364339 | 0.86 | S1PR3 (0.41) | ALDH1A1POLBMAPTRXFP1 | |
| SCHEMBL1364898 | 0.84 | ALDH1A1 (0.35) | ALDH1A1POLBMAPTAPLNRL3MBTL1 | |
| SCHEMBL1943284 | 0.84 | POLB (0.38) | ALDH1A1POLBP2RX7TP53MAPT | |
| SCHEMBL1945423 | 0.83 | POLB (0.38) | ALDH1A1POLBP2RX7TP53MAPT | |
| SCHEMBL1941900 | 0.81 | POLB (0.38) | ALDH1A1POLBP2RX7PDE10AAPLNR | |
| SCHEMBL1943735 | 0.80 | PIK3CD (0.39) | ALDH1A1POLBP2RX7APLNR | |
| SCHEMBL1945425 | 0.79 | P2RX7 (0.40) | ALDH1A1POLBP2RX7APLNRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110288120-A1 | ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS | H. LUNDBECK A/S (DK) | 2011-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110288120-A1 | ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS | KCNK3, KCNQ3, KCNN3 | ALDH1A1 2697/4885POLB 4034/4885P2RX7 693/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.