Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOC | P08134 | 1/20 | 0.41 |
| ▸ | RHOA | P61586 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 4/20 | 0.38 |
| ▸ | BRD2 | P25440 | 4/20 | 0.38 |
| ▸ | BRD3 | Q15059 | 3/20 | 0.38 |
| ▸ | BRDT | Q58F21 | 3/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | CPT1A | P50416 | 2/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.36 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4054289 | 0.92 | BRD4 (0.45) | RHOCRHOARORCALDH1A1LMNA | |
| SCHEMBL12570152 | 0.92 | RHOC (0.41) | RHOCRHOARORCALDH1A1LMNA | |
| SCHEMBL2004141 | 0.91 | OPRD1 (0.47) | RORCALDH1A1LMNABRD4BRD2 | |
| SCHEMBL12570153 | 0.89 | RAB9A (0.40) | RORCALDH1A1LMNABRD4BRD2 | |
| SCHEMBL12570314 | 0.89 | RORC (0.39) | RORCBRD4BRD2BRD3BRDT | |
| SCHEMBL2006988 | 0.88 | BRD4 (0.51) | RORCALDH1A1LMNABRD4BRD2 | |
| SCHEMBL2011173 | 0.88 | TDP1 (0.48) | RORCALDH1A1BRD4NR1H3NR1H2 | |
| SCHEMBL13669971 | 0.88 | TDP1 (0.48) | RORCALDH1A1BRD4NR1H3NR1H2 | |
| SCHEMBL13670322 | 0.87 | RORC (0.41) | RORCBRD4BRD2BRD3BRDT | |
| SCHEMBL2002378 | 0.87 | LMNA (0.47) | RORCLMNANR1H3NR1H2CPT1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960377-B2 | Substituted pyridoxazines | CARA THERAPEUTICS, INC. (US) | 2011-06-14 | — | — | US | claimed |
| US-7960377-B2 | Substituted pyridoxazines | CARA THERAPEUTICS, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| US-20090247502-A1 | SUBSTITUTED PYRIDOXAZINES | CARA THERAPEUTICS, INC. (US) | 2009-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247502-A1 | SUBSTITUTED PYRIDOXAZINES | CNR1, CNR2, TRPV1 | RHOC 4390/4885RHOA 4544/4885RORC 122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.