Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 2/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CYP24A1 | Q07973 | 3/20 | 0.39 |
| ▸ | CYP27A1 | Q02318 | 2/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14365306 | 0.82 | OPRM1 (0.38) | OPRM1OPRD1OPRK1ALDH1A1P2RX7 | |
| SCHEMBL2990058 | 0.82 | IDO1 (0.41) | SLC6A4P2RX7 | |
| SCHEMBL28206454 | 0.77 | HTT (0.48) | TSHRCYP24A1CYP26A1KMT2AMEN1 | |
| SCHEMBL27343744 | 0.76 | EED (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1738754 | 0.75 | CCR4 (0.39) | ALDH1A1TSHRCYP24A1CYP27A1CYP26A1 | |
| SCHEMBL4517793 | 0.72 | HSD11B1 (0.52) | OPRM1OPRD1OPRK1HTR1ASLC6A4 | |
| SCHEMBL4509869 | 0.72 | HTR1A (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14365029 | 0.71 | KMT2A (0.38) | ALDH1A1RAB9AKMT2AMEN1 | |
| SCHEMBL13675555 | 0.71 | PDCD1 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL16533002 | 0.71 | CA2 (0.46) | ALDH1A1TSHRCA2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090264650-A1 | Prophylactic/Therapeutic Agent for Diabetes | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264650-A1 | Prophylactic/Therapeutic Agent for Diabetes | HSD11B1, HSD17B1, HSD11B2 | PSEN1 1721/4885PSEN2 3561/4885APH1B 1342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.