Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | RECQL | P46063 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13675811 | 0.86 | LMNA (0.51) | LMNAMAPTNPSR1KMT2ARECQL | |
| SCHEMBL3924250 | 0.85 | CNR2 (0.46) | — | |
| SCHEMBL13675803 | 0.81 | LMNA (0.56) | LMNAMAPTNPSR1KMT2AKDM4E | |
| SCHEMBL13676281 | 0.78 | USP2 (0.48) | LMNAMAPTNPSR1KMT2ARECQL | |
| SCHEMBL13676256 | 0.76 | LMNA (0.56) | LMNAMAPTNPSR1KMT2ARECQL | |
| SCHEMBL13676283 | 0.73 | USP2 (0.51) | LMNAMAPTNPSR1KMT2ARECQL | |
| SCHEMBL8693115 | 0.73 | ALDH1A1 (0.69) | LMNAMAPTKMT2AKDM4EPOLB | |
| SCHEMBL10650984 | 0.72 | KMT2A (0.48) | LMNAMAPTKMT2ARECQLPOLB | |
| SCHEMBL17995258 | 0.71 | NR4A2 (0.69) | LMNAMAPTNPSR1KMT2AMEN1 | |
| SCHEMBL12479405 | 0.67 | LMNA (0.68) | LMNAMAPTNPSR1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7608633-B2 | Heteroaryl-substituted acetone derivatives as inhibitors of phospholipase A2 | MERCKLE GMBH (DE) | 2009-10-27 | — | — | US | disclosed |