Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PLA2G4A | P47712 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13903815 | 0.85 | MAPT (0.71) | LMNAMAPTSMN1; SMN2THRBMEN1 | |
| SCHEMBL3930481 | 0.85 | PLA2G4A (0.62) | PLA2G4A | |
| SCHEMBL13675815 | 0.81 | LMNA (0.56) | LMNAMAPTSMN1; SMN2THRBMEN1 | |
| SCHEMBL8693115 | 0.79 | ALDH1A1 (0.69) | LMNAMAPTGAAKMT2ATSHR | |
| SCHEMBL13675811 | 0.78 | LMNA (0.51) | LMNAMAPTSMN1; SMN2THRBMEN1 | |
| SCHEMBL13676282 | 0.77 | PPARG (0.39) | LMNAMAPTGAASMN1; SMN2MEN1 | |
| SCHEMBL12479405 | 0.75 | LMNA (0.68) | LMNAMAPTGAASMN1; SMN2KMT2A | |
| SCHEMBL13676257 | 0.74 | PLA2G4A (0.54) | LMNAMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL17995258 | 0.72 | NR4A2 (0.69) | LMNAMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL3922098 | 0.72 | PLA2G4A (0.56) | PLA2G4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7608633-B2 | Heteroaryl-substituted acetone derivatives as inhibitors of phospholipase A2 | MERCKLE GMBH (DE) | 2009-10-27 | — | — | US | disclosed |