Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13675815 | 0.86 | LMNA (0.56) | LMNAMAPTPOLBKMT2AKDM4E | |
| SCHEMBL13676280 | 0.79 | MAPT (0.45) | LMNAMAPTPOLBKMT2AKDM4E | |
| SCHEMBL13675803 | 0.78 | LMNA (0.56) | LMNAMAPTKMT2AKDM4ETHRB | |
| SCHEMBL13676258 | 0.77 | POLB (0.44) | LMNAMAPTPOLBKMT2AKDM4E | |
| SCHEMBL13676285 | 0.75 | AR (0.42) | LMNAMAPTPOLBKMT2AKDM4E | |
| SCHEMBL3924250 | 0.73 | CNR2 (0.46) | — | |
| SCHEMBL8693115 | 0.70 | ALDH1A1 (0.69) | LMNAMAPTPOLBKMT2AKDM4E | |
| SCHEMBL17995258 | 0.68 | NR4A2 (0.69) | LMNAMAPTPOLBKMT2ASMN1; SMN2 | |
| SCHEMBL19483271 | 0.66 | AR (0.50) | LMNAMAPTPOLBKMT2ATHRB | |
| SCHEMBL13676256 | 0.65 | LMNA (0.56) | LMNAMAPTPOLBKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7608633-B2 | Heteroaryl-substituted acetone derivatives as inhibitors of phospholipase A2 | MERCKLE GMBH (DE) | 2009-10-27 | — | — | US | disclosed |