Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 9/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 8/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ESRRG | P62508 | 3/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | ESRRB | O95718 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28031837 | 0.87 | HDAC1 (0.48) | EPHX2NR1H4HDAC3HDAC8HDAC6 | |
| SCHEMBL25356153 | 0.79 | HDAC1 (0.46) | EPHX2NR1H4HDAC3HDAC8HDAC6 | |
| SCHEMBL15508523 | 0.77 | TSHR (0.48) | EPHX2NR1H4TP53TSHR | |
| SCHEMBL28032403 | 0.72 | ALDH1A1 (0.52) | RXRARXRBALDH1A1HTT | |
| SCHEMBL5800200 | 0.71 | HDAC1 (0.47) | EPHX2NR1H4HDAC3HDAC8HDAC6 | |
| SCHEMBL27885381 | 0.71 | HDAC1 (0.47) | EPHX2NR1H4HDAC3HDAC8HDAC6 | |
| SCHEMBL28609678 | 0.69 | HDAC1 (0.46) | EPHX2NR1H4HDAC3HDAC8HDAC6 | |
| SCHEMBL13676268 | 0.69 | HDAC1 (0.46) | EPHX2NR1H4HDAC3HDAC8HDAC6 | |
| SCHEMBL28031818 | 0.69 | HDAC3 (0.47) | HDAC3HDAC6 | |
| SCHEMBL9003485 | 0.68 | HDAC1 (0.44) | EPHX2NR1H4TP53HDAC3HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090264424-A1 | VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS | AMGEN INC. | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264424-A1 | VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS | TRPV1, TRPV2, TRPV3 | EPHX2 4360/4885NR1H4 290/4885TP53 1958/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.