Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 9/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALDH1A3 | P47895 | 3/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.40 |
| ▸ | ABAT | P80404 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3680153 | 0.87 | PDE4B (0.45) | PDE4BALDH1A1TSHRPOLBALDH1A3 | |
| SCHEMBL16272283 | 0.86 | ALDH1A3 (0.45) | PDE4BALDH1A1TSHRPOLBALDH1A3 | |
| SCHEMBL8845986 | 0.85 | PDE4B (0.49) | PDE4BALDH1A1TSHRPOLBPDE3A | |
| SCHEMBL7356357 | 0.84 | PDE4B (0.42) | PDE4BPDE3APDE4DPDE4APDE4C | |
| SCHEMBL5905463 | 0.83 | PDE4B (0.48) | PDE4BALDH1A1TSHRPOLBPDE3A | |
| SCHEMBL70835 | 0.83 | ALDH1A1 (0.64) | PDE4BALDH1A1TSHRPDE3APDE4D | |
| SCHEMBL2840516 | 0.83 | ALDH1A1 (0.64) | PDE4BALDH1A1TSHRALDH1A3PDE3A | |
| SCHEMBL7560477 | 0.83 | ALDH1A1 (0.64) | PDE4BALDH1A1TSHRPDE3APDE4D | |
| SCHEMBL29808190 | 0.83 | ALDH1A1 (0.64) | PDE4BALDH1A1TSHRPDE3APDE4D | |
| SCHEMBL2847455 | 0.81 | ALDH1A1 (0.62) | PDE4BALDH1A1TSHRALDH1A3PDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9561201-B2 | Therapeutic compounds | FIBROTECH THERAPEUTICS PTY LTD (AU) | 2017-02-07 | — | — | US | disclosed |
| US-20140357628-A1 | THERAPEUTIC COMPOUNDS | FIBROTECH THERAPEUTICS PTY LTD (AU) | 2014-12-04 | — | — | US | disclosed |
| US-7601742-B2 | 4-(3-Hydroxy-4-methoxyphenyl)-pyrrolidin-2-one and derivatives; reverse transcriptase inhibitors; AIDS | IRM LLC (BM) | 2009-10-13 | — | — | US | disclosed |
| US-7495016-B2 | Pyrrolidones with anti-HIV activity | IRM LLC (BM) | 2009-02-24 | — | — | US | disclosed |
| US-20080255136-A1 | PYRROLIDONES WITH ANTI-HIV ACTIVITY | IRM LLC (BM) | 2008-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255136-A1 | PYRROLIDONES WITH ANTI-HIV ACTIVITY | PREP, DHPS, PDCD11 | PDE4B 1650/4885ALDH1A1 1894/4885TSHR 4841/4885 |
| US-20140357628-A1 | THERAPEUTIC COMPOUNDS | NFATC1, AADAC, NAT1 | PDE4B 1014/4885ALDH1A1 201/4885TSHR 4230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.