Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 13/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.40 |
| ▸ | FDPS | P14324 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 3/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13677643 | 0.84 | PDE4B (0.45) | PDE4BPDE3APDE4DPDE4APDE4C | |
| SCHEMBL12794525 | 0.78 | ADRB2 (0.48) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL8296638 | 0.76 | ADRB2 (0.47) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL13677650 | 0.76 | VCP (0.52) | PDE4B | |
| SCHEMBL24925307 | 0.75 | EIF4E (0.43) | PDE4A | |
| SCHEMBL21243673 | 0.75 | HTR2C (0.47) | PDE4BPDE4D | |
| SCHEMBL1047958 | 0.75 | ALDH1A1 (0.42) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL12760854 | 0.73 | S1PR1 (0.43) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL10333659 | 0.73 | FDPS (0.59) | FDPS | |
| SCHEMBL22991959 | 0.73 | PDE4B (0.79) | PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0538384-A4 | OXAMIDES | SMITHKLINE BEECHAM CORP (US) | 1995-04-12 | — | — | EP | disclosed |
| US-5393788-A | Phenylalkyl oxamides | SMITHKLINE BEECHAM CORPORATION (US) | 1995-02-28 | — | — | US | disclosed |
| EP-0538384-A1 | OXAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-04-28 | — | — | EP | disclosed |
| WO-1992000968-A1 | OXAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 1992-01-23 | — | — | WO | disclosed |