Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4519474 | 0.91 | MAPK14 (0.51) | MAPK14KDM4ERECQL | |
| SCHEMBL4522993 | 0.91 | CASP3 (0.49) | MAPK14KDM4ECASP3KMT2A | |
| SCHEMBL4501869 | 0.91 | ALDH1A1 (0.45) | MAPK14ALDH1A1KDM4EHPGDCASP3 | |
| SCHEMBL13678560 | 0.90 | CASP3 (0.44) | MAPK14ALDH1A1KDM4EHPGDRECQL | |
| SCHEMBL4513443 | 0.89 | GAA (0.49) | MAPK14KDM4ERECQLKMT2ARXFP1 | |
| SCHEMBL4513533 | 0.89 | MAPK14 (0.43) | MAPK14KDM4ERECQLCASP3KMT2A | |
| SCHEMBL4505724 | 0.89 | MAPK14 (0.43) | MAPK14KDM4ERECQLCASP3KMT2A | |
| SCHEMBL13678558 | 0.88 | MAPK14 (0.41) | MAPK14ALDH1A1KDM4EHPGDRECQL | |
| SCHEMBL4504766 | 0.87 | MAPK14 (0.40) | MAPK14ALDH1A1KDM4ERECQLKMT2A | |
| SCHEMBL13678553 | 0.84 | MAPK14 (0.53) | MAPK14ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090270350-A1 | Pyridinone Pyrazole Urea and Pyrimidinone Pyrazole Urea Derivatives | PFIZER INC. | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270350-A1 | Pyridinone Pyrazole Urea and Pyrimidinone Pyrazole Urea Derivatives | PDXK, UMPS, CDK2 | MAPK14 117/4885ALDH1A1 1197/4885KDM4E 1348/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.