Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4520277 | 0.90 | ALDH1A1 (0.45) | MAPK14ALDH1A1KDM4EHPGDMAPK1 | |
| SCHEMBL13678560 | 0.89 | CASP3 (0.44) | MAPK14ALDH1A1KDM4EHPGDRECQL | |
| SCHEMBL13678554 | 0.88 | MAPK14 (0.46) | MAPK14ALDH1A1KDM4EHPGDRECQL | |
| SCHEMBL4510559 | 0.88 | PDE1A (0.41) | MAPK14ALDH1A1KDM4ERECQLCASP3 | |
| SCHEMBL4499561 | 0.88 | GAA (0.49) | MAPK14KDM4ERECQLKMT2ARXFP1 | |
| SCHEMBL4506364 | 0.86 | MAPK14 (0.40) | MAPK14ALDH1A1KDM4EHPGDRECQL | |
| SCHEMBL4511553 | 0.84 | MAPK14 (0.41) | MAPK14ALDH1A1KDM4ERECQLKMT2A | |
| SCHEMBL4519474 | 0.81 | MAPK14 (0.51) | MAPK14KDM4ERECQL | |
| SCHEMBL4522993 | 0.80 | CASP3 (0.49) | MAPK14KDM4ECASP3KMT2A | |
| SCHEMBL4501869 | 0.80 | ALDH1A1 (0.45) | MAPK14ALDH1A1KDM4EHPGDCASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090270350-A1 | Pyridinone Pyrazole Urea and Pyrimidinone Pyrazole Urea Derivatives | PFIZER INC. | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270350-A1 | Pyridinone Pyrazole Urea and Pyrimidinone Pyrazole Urea Derivatives | PDXK, UMPS, CDK2 | MAPK14 117/4885ALDH1A1 1197/4885KDM4E 1348/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.