Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.49 |
| ▸ | POLB | P06746 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | EEF2K | O00418 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680476 | 0.85 | TSHR (0.47) | RAB9APOLBNPC1SMN1; SMN2PPARA | |
| SCHEMBL13680522 | 0.80 | RAB9A (0.55) | RAB9APOLBNPC1SMN1; SMN2TP53 | |
| SCHEMBL13680947 | 0.80 | TP53 (0.46) | RAB9APOLBNPC1SMN1; SMN2TP53 | |
| SCHEMBL13680537 | 0.79 | KIF11 (0.54) | RAB9APOLBNPC1SMN1; SMN2PPARA | |
| SCHEMBL13680489 | 0.78 | SMN1; SMN2 (0.47) | RAB9APOLBNPC1SMN1; SMN2TP53 | |
| SCHEMBL13680523 | 0.78 | RAB9A (0.51) | RAB9APOLBNPC1SMN1; SMN2PPARA | |
| SCHEMBL3302544 | 0.76 | POLB (0.69) | RAB9APOLBNPC1SMN1; SMN2TP53 | |
| SCHEMBL13680741 | 0.73 | KIF11 (0.43) | RAB9APOLBNPC1SMN1; SMN2TP53 | |
| SCHEMBL12994648 | 0.73 | POLB (0.66) | RAB9APOLBNPC1SMN1; SMN2TP53 | |
| SCHEMBL8198560 | 0.72 | CYP3A4 (0.60) | RAB9APOLBNPC1SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |