Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.45 |
| ▸ | PPARA | Q07869 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPY1R | P25929 | 1/20 | 0.43 |
| ▸ | NPY2R | P49146 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680522 | 0.85 | RAB9A (0.55) | SMN1; SMN2RAB9AKMT2ANPC1MEN1 | |
| SCHEMBL13680537 | 0.84 | KIF11 (0.54) | SMN1; SMN2RAB9AKMT2ANPC1MEN1 | |
| SCHEMBL13680523 | 0.82 | RAB9A (0.51) | SMN1; SMN2RAB9AKMT2ANPC1MEN1 | |
| SCHEMBL13680476 | 0.81 | TSHR (0.47) | SMN1; SMN2RAB9AKMT2ANPC1MEN1 | |
| SCHEMBL13680524 | 0.79 | MAPT (0.58) | SMN1; SMN2RAB9AKMT2ANPC1MEN1 | |
| SCHEMBL13680748 | 0.78 | CYP2E1 (0.40) | RAB9ANPC1POLBPPARAALDH1A1 | |
| SCHEMBL13680574 | 0.78 | RAB9A (0.49) | SMN1; SMN2RAB9AKMT2ANPC1MEN1 | |
| SCHEMBL13680741 | 0.78 | KIF11 (0.43) | SMN1; SMN2RAB9AKMT2ANPC1MEN1 | |
| SCHEMBL13680934 | 0.77 | TP53 (0.51) | SMN1; SMN2KMT2AMEN1POLBL3MBTL1 | |
| SCHEMBL8198560 | 0.77 | CYP3A4 (0.60) | SMN1; SMN2RAB9AKMT2ANPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |