Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | STAT1 | P42224 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | GBA1 | P04062 | 5/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CCR1 | P32246 | 1/20 | 0.46 |
| ▸ | CCR8 | P51685 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | SMO | Q99835 | 1/20 | 0.45 |
| ▸ | PEPD | P12955 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12270039 | 0.86 | KMT2A (0.61) | RAB9ANPC1MAPTMEN1KMT2A | |
| SCHEMBL13680672 | 0.84 | CYP1A2 (0.46) | KIF11RAB9ANPC1MAPTMEN1 | |
| SCHEMBL13537053 | 0.83 | SMN1; SMN2 (0.49) | RAB9ANPC1MAPTMEN1KMT2A | |
| SCHEMBL13680553 | 0.83 | GBA1 (0.52) | RAB9ANPC1MAPTMEN1KMT2A | |
| SCHEMBL13680483 | 0.82 | TSHR (0.49) | RAB9ANPC1MAPTMEN1KMT2A | |
| SCHEMBL29949633 | 0.79 | TGFBR1 (0.50) | CCR1CCR8CYP2A6KDR | |
| SCHEMBL12270020 | 0.79 | TGFBR1 (0.50) | CCR1CCR8CYP2A6KDR | |
| SCHEMBL3422361 | 0.77 | CCR1 (0.75) | RAB9AMAPTMEN1KMT2ACCR1 | |
| SCHEMBL11175103 | 0.76 | KIF11 (0.66) | KIF11NPC1MAPTMEN1KMT2A | |
| SCHEMBL13680556 | 0.75 | MEN1 (0.46) | KIF11RAB9ANPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |