Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 4/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.60 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.60 |
| ▸ | QPCT | Q16769 | 7/20 | 0.50 |
| ▸ | QPCTL | Q9NXS2 | 5/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CCR1 | P32246 | 1/20 | 0.46 |
| ▸ | CCR8 | P51685 | 1/20 | 0.46 |
| ▸ | MMP12 | P39900 | 1/20 | 0.45 |
| ▸ | PRKCI | P41743 | 1/20 | 0.45 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15640140 | 0.85 | TGFBR1 (0.55) | TGFBR1CYP2D6TGFBR2MAP3K20QPCT | |
| SCHEMBL6760983 | 0.81 | TGFBR1 (0.71) | TGFBR1CYP2D6TGFBR2MAP3K20KDM4E | |
| SCHEMBL13680559 | 0.78 | RAB9A (0.56) | TGFBR1KDM4ENPC1ALDH1A1HPGD | |
| SCHEMBL13680531 | 0.78 | QPCT (0.60) | QPCTQPCTLBRD4CREBBPKDM4E | |
| SCHEMBL8634290 | 0.77 | QPCT (0.68) | QPCTQPCTLBRD4CREBBPKDM4E | |
| SCHEMBL11235922 | 0.76 | QPCT (0.58) | TGFBR1TGFBR2QPCTQPCTLBRD4 | |
| SCHEMBL25942078 | 0.76 | TGFBR1 (0.73) | TGFBR1CYP2D6TGFBR2MAP3K20QPCT | |
| SCHEMBL15551561 | 0.74 | QPCT (0.65) | QPCTQPCTLBRD4CREBBPKDM4E | |
| SCHEMBL21364016 | 0.74 | TGFBR1 (0.55) | TGFBR1CYP2D6TGFBR2MAP3K20 | |
| SCHEMBL22418756 | 0.73 | QPCT (0.64) | QPCTQPCTLKDM4ENPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |