Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 7/20 | 0.51 |
| ▸ | HSD17B2 | P37059 | 7/20 | 0.51 |
| ▸ | ERN1 | O75460 | 1/20 | 0.44 |
| ▸ | POLQ | O75417 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CTSA | P10619 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | GAK | O14976 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5158289 | 0.84 | KDR (0.50) | ERN1KDRDYRK1AALDH1A1TSHR | |
| SCHEMBL21876156 | 0.83 | MAP4K4 (0.46) | HSD17B1HSD17B2ERN1KDRDYRK1A | |
| SCHEMBL3459364 | 0.80 | HSD17B1 (0.54) | HSD17B1HSD17B2KDRHDAC1HDAC6 | |
| SCHEMBL28339551 | 0.79 | ERN1 (0.41) | HSD17B1HSD17B2ERN1POLQKDR | |
| SCHEMBL20500563 | 0.77 | KMO (0.57) | MEN1KMT2A | |
| SCHEMBL9954919 | 0.77 | HSD17B1 (0.51) | HSD17B1HSD17B2KDRHDAC1HDAC6 | |
| SCHEMBL9954813 | 0.77 | ALDH1A1 (0.54) | HSD17B1HSD17B2KDRHDAC1HDAC6 | |
| SCHEMBL18122016 | 0.75 | HSD17B1 (0.57) | HSD17B1HSD17B2KDRHDAC6MEN1 | |
| SCHEMBL11965515 | 0.75 | HSD17B1 (0.50) | HSD17B1HSD17B2KDRHDAC1HDAC6 | |
| SCHEMBL2410374 | 0.74 | HSD17B1 (0.56) | HSD17B1HSD17B2KDRHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |