Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 2/20 | 0.45 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | CCR8 | P51685 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680676 | 0.85 | CYP2A6 (0.47) | CYP2A6GRM5CCR1CCR8RAB9A | |
| SCHEMBL13537053 | 0.79 | SMN1; SMN2 (0.49) | CYP2A6CCR1CCR8RAB9AKMT2A | |
| SCHEMBL13680544 | 0.77 | CNR1 (0.51) | CYP2A6RAB9AKMT2AMEN1MAPT | |
| SCHEMBL13680675 | 0.77 | CCR1 (0.52) | CYP2A6GRM5CCR1CCR8MAPT | |
| SCHEMBL13680554 | 0.77 | GRM5 (0.53) | CYP2A6GRM5CCR1CCR8KMT2A | |
| SCHEMBL13680657 | 0.75 | FAAH (0.46) | AAK1 | |
| SCHEMBL13680678 | 0.74 | CYP2A6 (0.51) | CYP2A6GRM5CCR1CCR8RAB9A | |
| SCHEMBL13680586 | 0.73 | CCR1 (0.52) | CYP2A6GRM5CCR1CCR8KMT2A | |
| SCHEMBL13680679 | 0.72 | CCR1 (0.60) | CYP2A6GRM5CCR1CCR8RAB9A | |
| SCHEMBL8241210 | 0.72 | HPGD (0.46) | RAB9AKMT2AMEN1HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |