Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | S100A4 | P26447 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL890218 | 0.77 | NPC1 (0.50) | MAPTKDM4EALDH1A1GLAGAA | |
| SCHEMBL1356959 | 0.74 | LMNA (0.70) | LMNAMAPTKDM4EALDH1A1GLA | |
| SCHEMBL1575023 | 0.73 | LMNA (0.59) | LMNAMAPTKDM4EALDH1A1GLA | |
| SCHEMBL299865 | 0.73 | KDM4E (0.45) | LMNAMAPTKDM4EALDH1A1GLA | |
| SCHEMBL12569052 | 0.72 | LMNA (0.68) | LMNAMAPTKDM4EALDH1A1GLA | |
| SCHEMBL8575623 | 0.72 | LMNA (0.68) | LMNAMAPTKDM4EALDH1A1GLA | |
| SCHEMBL13680664 | 0.72 | KDM4E (0.50) | LMNAMAPTKDM4EALDH1A1GLA | |
| SCHEMBL299141 | 0.72 | RAB9A (0.52) | LMNAMAPTKDM4EALDH1A1GLA | |
| SCHEMBL13680487 | 0.70 | ALDH1A1 (0.49) | MAPTKDM4EALDH1A1GAACYP3A4 | |
| SCHEMBL10147188 | 0.70 | PDE10A (0.40) | MAPTKDM4EALDH1A1GLACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |