Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | NOS1 | P29475 | 2/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13681281 | 0.78 | LOXL2 (0.41) | SMN1; SMN2NOS1PDE10ACYP3A4CYP2E1 | |
| SCHEMBL13680760 | 0.76 | PDE10A (0.39) | SMN1; SMN2NOS1PDE10ACYP3A4CYP2E1 | |
| SCHEMBL13680758 | 0.76 | DYRK1A (0.43) | SMN1; SMN2NOS1PDE10ACYP3A4CYP2E1 | |
| SCHEMBL13680737 | 0.76 | ADORA2A (0.39) | SMN1; SMN2NOS1PDE10ACYP3A4CYP2E1 | |
| SCHEMBL6711413 | 0.73 | SMN1; SMN2 (0.67) | BACE1SMN1; SMN2NOS1ALDH1A1HSD17B10 | |
| SCHEMBL22631683 | 0.71 | PDE10A (0.36) | SMN1; SMN2NOS1PDE10ACYP3A4CYP2E1 | |
| SCHEMBL21242477 | 0.71 | NOS1 (0.55) | BACE1SMN1; SMN2NOS1ALDH1A1HSD17B10 | |
| SCHEMBL18157874 | 0.71 | SMN1; SMN2 (0.55) | SMN1; SMN2NOS1PDE10ACYP3A4CYP2E1 | |
| SCHEMBL13680738 | 0.70 | CYP3A4 (0.50) | SMN1; SMN2NOS1PDE10ACYP3A4CYP2E1 | |
| SCHEMBL3346355 | 0.70 | SMN1; SMN2 (0.47) | SMN1; SMN2NOS1PDE10ACYP3A4CYP2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |