Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.35 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.35 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 5/20 | 0.34 |
| ▸ | NPC1 | O15118 | 4/20 | 0.34 |
| ▸ | FDPS | P14324 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680759 | 0.76 | BACE1 (0.49) | PDE10ACYP3A4CYP2C9CYP2E1CYP2A6 | |
| SCHEMBL13680737 | 0.73 | ADORA2A (0.39) | PDE10ACYP3A4CYP2C9CYP2E1CYP2A6 | |
| SCHEMBL13680758 | 0.73 | DYRK1A (0.43) | PDE10ACYP3A4CYP2C9CYP2E1CYP2A6 | |
| SCHEMBL13681065 | 0.73 | ALDH1A1 (0.33) | LMNALIMK1RAB9ACDK2CCNT1 | |
| SCHEMBL13681281 | 0.72 | LOXL2 (0.41) | PDE10ACYP3A4CYP2C9CYP2E1CYP2A6 | |
| SCHEMBL259247 | 0.69 | — | — | |
| SCHEMBL13680746 | 0.69 | CYP3A4 (0.47) | PDE10ACYP3A4CYP2C9CYP2E1CYP2A6 | |
| SCHEMBL22631683 | 0.69 | PDE10A (0.36) | PDE10ACYP3A4CYP2C9CYP2E1CYP2A6 | |
| SCHEMBL13680697 | 0.69 | KDR (0.51) | CYP3A4CYP2C9CYP2A6KDRLMNA | |
| SCHEMBL18157874 | 0.69 | SMN1; SMN2 (0.55) | PDE10ACYP3A4CYP2C9CYP2E1CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |