Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.50 |
| ▸ | BCR | P11274 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | CASR | P41180 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24197395 | 0.84 | MAOB (0.59) | MAOBTSHRALDH1A1SMN1; SMN2GPR52 | |
| SCHEMBL2302446 | 0.84 | FFAR4 (0.46) | FFAR1KDM4EALDH1A1SMN1; SMN2GPR52 | |
| SCHEMBL13680791 | 0.83 | GAA (0.55) | HPGDLMNAFFAR1SMN1; SMN2GPR52 | |
| SCHEMBL13680790 | 0.83 | FFAR1 (0.45) | FFAR1ANO1GPR52 | |
| SCHEMBL13680783 | 0.82 | FFAR1 (0.45) | FFAR1GPR52 | |
| SCHEMBL417948 | 0.82 | TAAR1 (0.61) | CHRM2CHRM1CHRM3GPR52 | |
| SCHEMBL418611 | 0.82 | GPR52 (0.50) | FFAR1BACE1GPR52 | |
| SCHEMBL13680786 | 0.81 | CHRM2 (0.46) | ABL1CHRM2CHRM1CHRM3 | |
| SCHEMBL8367734 | 0.81 | DRD1 (0.52) | — | |
| SCHEMBL16631060 | 0.81 | FFAR1 (0.56) | MAOBFFAR1PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |