Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | SERPINE1 | P05121 | 4/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | AGXT | P21549 | 1/20 | 0.40 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5537502 | 0.84 | CHRM2 (0.62) | CHRM2CHRM1CHRM3DAOCHRM5 | |
| SCHEMBL13680784 | 0.81 | ABL1 (0.50) | CHRM2CHRM1CHRM3ABL1 | |
| SCHEMBL13680787 | 0.81 | AGXT (0.56) | SLC13A5AGXT | |
| SCHEMBL13680798 | 0.81 | CYP1A2 (0.38) | CHRM2CHRM1CHRM3SLC13A5MRGPRX4 | |
| SCHEMBL8367734 | 0.81 | DRD1 (0.52) | MRGPRX4DAOAGXT | |
| SCHEMBL584633 | 0.80 | GPR84 (0.49) | CHRM2CHRM1CHRM3TRPV1DAO | |
| SCHEMBL2302446 | 0.80 | FFAR4 (0.46) | AGXT | |
| SCHEMBL13099463 | 0.79 | BCL2 (0.51) | SLC13A5SERPINE1MRGPRX4ABL1SCN5A | |
| SCHEMBL13680783 | 0.79 | FFAR1 (0.45) | — | |
| SCHEMBL418611 | 0.78 | GPR52 (0.50) | AGXT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |