Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | BCL2 | P10415 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | GPR52 | Q9Y2T5 | 2/20 | 0.45 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 4/20 | 0.41 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.41 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.40 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13681324 | 0.87 | BCL2 (0.63) | BCL2GPR52AOC3TRIM24TRIM33 | |
| SCHEMBL13680794 | 0.85 | AOC3 (0.53) | BCL2GPR52AOC3TRIM24TRIM33 | |
| SCHEMBL13680789 | 0.85 | ERN1 (0.50) | MAPTBCL2 | |
| SCHEMBL13680801 | 0.85 | ERN1 (0.50) | BCL2GPR52HSD17B1LMNAAOC3 | |
| SCHEMBL13680795 | 0.85 | BCL2 (0.47) | MAPTBCL2SMN1; SMN2GPR52LMNA | |
| SCHEMBL13680791 | 0.82 | GAA (0.55) | MAPTBCL2SMN1; SMN2GPR52LMNA | |
| SCHEMBL13680796 | 0.82 | AOC3 (0.56) | MAPTSMN1; SMN2HSD17B1LMNAAOC3 | |
| SCHEMBL13680790 | 0.81 | FFAR1 (0.45) | BCL2GPR52LIPGPTGS2 | |
| SCHEMBL418611 | 0.81 | GPR52 (0.50) | BCL2GPR52AOC3CYP19A1 | |
| SCHEMBL13099462 | 0.80 | BCL2 (0.76) | MAPTBCL2SMN1; SMN2HSD17B1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |