Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 4/20 | 0.50 |
| ▸ | CYP4A11 | Q02928 | 4/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 2/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680811 | 0.85 | HIF1A (0.48) | CYP4F2CYP4A11HIF1A | |
| SCHEMBL13680789 | 0.81 | ERN1 (0.50) | CYP4F2CYP4A11ERN1 | |
| SCHEMBL31747478 | 0.81 | MAPK1 (0.53) | CYP4A11HIF1AMAPK1DYRK1A | |
| SCHEMBL13680810 | 0.80 | HSD17B1 (0.53) | ERN1 | |
| SCHEMBL13680851 | 0.79 | MAPK1 (0.43) | MAPK1DYRK1AFAAH | |
| SCHEMBL13680808 | 0.78 | EPHX2 (0.38) | CYP4F2CYP4A11HIF1ACDK8 | |
| SCHEMBL13680499 | 0.77 | MAPK1 (0.51) | CYP4F2CYP4A11MAPK1DYRK1ACDK8 | |
| SCHEMBL23380565 | 0.76 | MAPT (0.51) | CYP4F2CYP4A11MAPK1DYRK1ACDK8 | |
| SCHEMBL13680797 | 0.76 | CYP11B2 (0.38) | CYP4F2CYP4A11HIF1ACDK8 | |
| SCHEMBL11041168 | 0.74 | MAPK1 (0.59) | HIF1AMAPK1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |