Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.36 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | AGXT | P21549 | 1/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680808 | 0.83 | EPHX2 (0.38) | GRIN1GRIN2BCDK8HIF1ACYP4F2 | |
| SCHEMBL13680809 | 0.82 | GRIN1 (0.41) | GRIN1GRIN2BCDK8 | |
| SCHEMBL5675196 | 0.81 | TAAR1 (0.55) | CYP11B2CDK8DRD2TAAR1 | |
| SCHEMBL13680810 | 0.80 | HSD17B1 (0.53) | CYP2A6 | |
| SCHEMBL13680811 | 0.80 | HIF1A (0.48) | HIF1ACYP4F2CYP4A11 | |
| SCHEMBL13680798 | 0.79 | CYP1A2 (0.38) | GRIN1GRIN2BAGXTCYP4F2CYP4A11 | |
| SCHEMBL13680805 | 0.78 | EPHX2 (0.55) | CYP11B2CYP2E1CYP2A6CYP2B6CYP11B1 | |
| SCHEMBL24721758 | 0.77 | BCL2 (0.47) | CYP11B2GRIN1GRIN2BCYP2E1CYP2A6 | |
| SCHEMBL16675747 | 0.77 | PRKCI (0.53) | CYP11B2CYP2E1CYP2A6CYP2B6CDK8 | |
| SCHEMBL5215922 | 0.77 | CYP11B2 (0.42) | CYP11B2GRIN1GRIN2BCYP2E1CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |