Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.42 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.35 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 5/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
| ▸ | NCF1 | P14598 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 2/20 | 0.34 |
| ▸ | NOS2 | P35228 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680848 | 0.79 | ADK (0.40) | KCNH2HDAC6 | |
| SCHEMBL3583708 | 0.78 | HTR1A (0.42) | PDE10AITGB1ITGA5ACACBHTR1A | |
| SCHEMBL23343768 | 0.77 | PDE10A (0.45) | PDE10AITGB1ITGA5ACACBHTR1A | |
| SCHEMBL6193822 | 0.77 | SMN1; SMN2 (0.45) | KCNH2NOS1NOS2NPSR1HDAC6 | |
| SCHEMBL4718743 | 0.76 | — | — | |
| SCHEMBL13680831 | 0.75 | PDE10A (0.37) | PDE10A | |
| SCHEMBL14182008 | 0.74 | PDE10A (0.41) | PDE10AACACBHTR1AKCNH2NCF1 | |
| SCHEMBL13680814 | 0.73 | KCNH2 (0.35) | KCNH2NPSR1 | |
| SCHEMBL1463893 | 0.73 | PARP1 (0.36) | HTR1AKCNH2NPSR1 | |
| SCHEMBL13680820 | 0.73 | CYP3A4 (0.39) | ACACBKCNH2NPSR1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |