Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADK | P55263 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.38 |
| ▸ | APP | P05067 | 5/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 4/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680831 | 0.83 | PDE10A (0.37) | ADKMAPTAPPSYK | |
| SCHEMBL13680847 | 0.83 | PDE10A (0.43) | KCNH2SCN9ANPC1RAB9A | |
| SCHEMBL13680846 | 0.81 | MAPT (0.40) | MAPTSCN9ASYK | |
| SCHEMBL13680849 | 0.80 | SCN9A (0.43) | MAPTSCN9AMTOR | |
| SCHEMBL13680826 | 0.79 | PDE10A (0.42) | KCNH2HDAC6 | |
| SCHEMBL13680834 | 0.79 | PDE10A (0.39) | MAPTPOLBRAB9A | |
| SCHEMBL13680850 | 0.77 | TRPV3 (0.53) | KCNH2SCN9A | |
| SCHEMBL13680954 | 0.76 | KDM4E (0.40) | MAPTAPPNPC1POLBGAA | |
| SCHEMBL13680837 | 0.76 | ALDH1A1 (0.40) | — | |
| SCHEMBL3854280 | 0.76 | MEN1 (0.50) | KCNH2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |