Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PDE8B | O95263 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2089551 | 1.00 | OPRM1 (0.39) | OPRM1OPRL1MAOAMAOBNOTUM | |
| SCHEMBL24115287 | 0.78 | NOTUM (0.37) | NOTUMSIGMAR1NPC1PKMRAB9A | |
| SCHEMBL12387928 | 0.78 | SIGMAR1 (0.36) | NOTUMSIGMAR1ALDH1A1ACE | |
| SCHEMBL28280223 | 0.77 | ADRA2A (0.41) | NOTUMCYP1A2CYP2D6ACHE | |
| SCHEMBL17559354 | 0.75 | ACE (0.46) | ALDH1A1ACE | |
| SCHEMBL5243620 | 0.75 | ACE (0.46) | ALDH1A1ACE | |
| SCHEMBL3898933 | 0.75 | ACE (0.46) | ALDH1A1ACE | |
| SCHEMBL19473353 | 0.74 | ADORA2A (0.33) | NOTUMSIGMAR1ALDH1A1ACE | |
| SCHEMBL19473382 | 0.74 | ADORA2A (0.33) | NOTUMSIGMAR1ALDH1A1ACE | |
| SCHEMBL10065836 | 0.73 | OPRM1 (0.44) | OPRM1OPRL1NOTUMALDH1A1PDE8B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017153513-A1 | TETRAHYDROISOQUINOLINES AS PRMT5 INHIBITORS | CTXT PTY LIMITED (AU) | 2017-09-14 | — | — | WO | disclosed |
| US-7585878-B2 | Benzamide derivative or salt thereof | ASTELLAS PHARMA INC. (JP) | 2009-09-08 | — | — | US | disclosed |