Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | STAT3 | P40763 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13184255 | 0.77 | MAPT (0.37) | L3MBTL1KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL13861497 | 0.74 | TSHR (0.42) | KDM4EALDH1A1HSD17B10HPGDMAPT | |
| SCHEMBL14044112 | 0.73 | GRM2 (0.36) | L3MBTL1KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL17067025 | 0.68 | LMNA (0.41) | L3MBTL1KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL14768604 | 0.66 | NPC1 (0.47) | L3MBTL1KDM4EALDH1A1MAPTLMNA | |
| SCHEMBL104647 | 0.64 | ALDH1A1 (0.41) | KDM4EALDH1A1HSD17B10HPGDMAPT | |
| SCHEMBL19505110 | 0.63 | CYP11B2 (0.41) | CYP11B2 | |
| SCHEMBL3945905 | 0.63 | NPC1 (0.44) | L3MBTL1KDM4EALDH1A1LMNATSHR | |
| SCHEMBL22900713 | 0.62 | PDE4A (0.47) | KDM4EALDH1A1ELANEKMT2ANPC1 | |
| SCHEMBL8306766 | 0.62 | POLB (0.60) | KDM4EALDH1A1MAPTLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |
| US-7589199-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2009-09-15 | — | — | US | disclosed |