Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | SPR | P35270 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PROKR1 | Q8TCW9 | 3/20 | 0.35 |
| ▸ | KCNT1 | Q5JUK3 | 1/20 | 0.34 |
| ▸ | JMJD6 | Q6NYC1 | 3/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.34 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
| ▸ | CCR9 | P51686 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 2/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | XIAP | P98170 | 1/20 | 0.33 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.33 |
| ▸ | WNT1 | P04628 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13184425 | 0.78 | ALDH1A1 (0.44) | SPRL3MBTL1POLBKDM4E | |
| SCHEMBL13683131 | 0.78 | GRM5 (0.42) | GRM5PROKR1KCNT1JMJD6CSNK1D | |
| SCHEMBL3356107 | 0.75 | UHRF1 (0.50) | PROKR1CCR9KDM5AKDM4CKDM5B | |
| SCHEMBL13184401 | 0.74 | KDM4E (0.39) | GRM5PROKR1KCNT1JMJD6CCR9 | |
| SCHEMBL13683178 | 0.73 | KMT2A (0.45) | L3MBTL1KDM4EGSK3B | |
| SCHEMBL13184263 | 0.72 | BAZ2B (0.47) | L3MBTL1PROKR1JMJD6CCR9POLB | |
| SCHEMBL16200404 | 0.69 | POLB (0.43) | GRM5PROKR1JMJD6CCR9POLB | |
| SCHEMBL16200174 | 0.69 | DYRK1A (0.41) | GRM5KCNT1CSNK1DCSNK1EPOLB | |
| SCHEMBL13683180 | 0.68 | KDM4E (0.41) | L3MBTL1KDM4E | |
| SCHEMBL19556155 | 0.68 | L3MBTL1 (0.42) | L3MBTL1TTRPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324216-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-20100240618-A1 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX, INC. (US) | 2010-09-23 | — | — | US | disclosed |
| US-7589199-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2009-09-15 | — | — | US | disclosed |
| US-7435830-B2 | Bicyclic and bridged nitrogen heterocycles | CHEMOCENTRYX, INC. (US) | 2008-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240618-A1 | SUBSTITUTED PIPERAZINES | CCR1, CCR3, CCRL2 | GRM5 177/4885SPR 2083/4885L3MBTL1 1589/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.