Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | GALR3 | O60755 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | GLS | O94925 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13184311 | 0.74 | KDM4E (0.33) | KDM4EADORA2AADORA2BSMN1; SMN2 | |
| SCHEMBL13184164 | 0.70 | ADORA2A (0.36) | KDM4EADORA2AADORA2BLMNASMN1; SMN2 | |
| SCHEMBL16200255 | 0.68 | SMN1; SMN2 (0.38) | KDM4EADORA2AADORA2BLMNASMN1; SMN2 | |
| SCHEMBL16200075 | 0.67 | LMNA (0.41) | KDM4ELMNAKMT2ASMN1; SMN2 | |
| SCHEMBL13184163 | 0.67 | CYP3A4 (0.38) | KDM4EADORA2AADORA2BGALR3LMNA | |
| SCHEMBL13683097 | 0.64 | SMN1; SMN2 (0.56) | KDM4ELMNAKMT2ASMN1; SMN2 | |
| SCHEMBL16200076 | 0.64 | CHRNB2 (0.45) | KDM4ESMN1; SMN2 | |
| SCHEMBL16202027 | 0.64 | KAT7 (0.40) | MAPK10 | |
| SCHEMBL1196791 | 0.62 | — | — | |
| SCHEMBL1086373 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324216-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-7589199-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2009-09-15 | — | — | US | disclosed |
| US-7435830-B2 | Bicyclic and bridged nitrogen heterocycles | CHEMOCENTRYX, INC. (US) | 2008-10-14 | — | — | US | disclosed |