Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 4/20 | 0.61 |
| ▸ | TBXAS1 | P24557 | 12/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13683753 | 0.84 | LMNA (0.50) | KMT2AJAK2JAK1TYK2LMNA | |
| SCHEMBL13683424 | 0.83 | NOS1 (0.56) | NOS1TBXAS1KMT2AMEN1LMNA | |
| SCHEMBL13683761 | 0.79 | HRH3 (0.54) | KMT2AATM | |
| SCHEMBL8686274 | 0.78 | NOS1 (1.00) | NOS1TBXAS1KMT2AMEN1LMNA | |
| SCHEMBL10928050 | 0.73 | TBXAS1 (1.00) | TBXAS1KMT2AMEN1LMNA | |
| SCHEMBL10747686 | 0.73 | TBXAS1 (1.00) | TBXAS1KMT2AMEN1LMNA | |
| SCHEMBL10751356 | 0.73 | TBXAS1 (0.79) | TBXAS1KMT2AMEN1LMNA | |
| SCHEMBL3863181 | 0.72 | TRPV1 (0.44) | NOS1TBXAS1LMNA | |
| SCHEMBL8685446 | 0.72 | NOS1 (1.00) | NOS1TBXAS1KMT2AMEN1LMNA | |
| SCHEMBL6476742 | 0.72 | TBXAS1 (0.59) | TBXAS1KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7592373-B2 | Amide compounds with MCH antagonistic activity and medicaments comprising these compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-09-22 | — | — | US | disclosed |