Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 4/20 | 1.00 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | TBXAS1 | P24557 | 7/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | LTA4H | P09960 | 1/20 | 0.60 |
| ▸ | ATP4A | P20648 | 1/20 | 0.60 |
| ▸ | ATP4B | P51164 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8685446 | 0.93 | NOS1 (1.00) | NOS1HMOX1KDM4ETBXAS1MEN1 | |
| SCHEMBL13761576 | 0.85 | MEN1 (0.86) | NOS1KDM4EALDH1A1MAPK1TBXAS1 | |
| SCHEMBL13214748 | 0.80 | NOS1 (0.67) | NOS1KDM4EALDH1A1MAPK1TBXAS1 | |
| SCHEMBL8690248 | 0.80 | KMT2A (0.83) | NOS1KDM4EALDH1A1MAPK1TBXAS1 | |
| SCHEMBL76839 | 0.80 | KDM4E (0.72) | NOS1KDM4EALDH1A1MAPK1TBXAS1 | |
| SCHEMBL305632 | 0.80 | ALDH1A1 (0.72) | NOS1KDM4EALDH1A1MAPK1TBXAS1 | |
| SCHEMBL13246359 | 0.80 | QPCT (0.85) | NOS1KDM4EALDH1A1MAPK1TBXAS1 | |
| SCHEMBL8684965 | 0.80 | MAPK1 (1.00) | NOS1KDM4EALDH1A1MAPK1TBXAS1 | |
| SCHEMBL10785887 | 0.80 | KDM4E (0.72) | NOS1KDM4EALDH1A1MAPK1TBXAS1 | |
| SCHEMBL10370478 | 0.80 | TBXAS1 (1.00) | NOS1KDM4EALDH1A1MAPK1TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5708171-A | HISTAMINE H3-RECEPTOR ANTAGONIST | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1998-01-13 | — | — | US | claimed |
| US-5708171-A | HISTAMINE H3-RECEPTOR ANTAGONIST | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1998-01-13 | — | — | US | disclosed |