Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.40 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.40 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2031083 | 0.84 | HSD11B1 (0.46) | LMNAHSD11B1TRPV1MALT1 | |
| SCHEMBL1367888 | 0.84 | HSD11B1 (0.46) | LMNAHSD11B1TRPV1MALT1 | |
| SCHEMBL1367550 | 0.81 | EPHX2 (0.52) | HSD11B1TRPV1 | |
| SCHEMBL1370146 | 0.79 | LMNA (0.59) | LMNAHSD11B1TRPV1MALT1NPSR1 | |
| SCHEMBL20244837 | 0.75 | HSD11B1 (0.46) | HSD11B1TRPV1AVPR1AMALT1HTR7 | |
| SCHEMBL2743003 | 0.74 | TRPV1 (0.46) | HSD11B1TRPV1AVPR1A | |
| SCHEMBL4425614 | 0.74 | TRPV1 (0.46) | HSD11B1TRPV1AVPR1A | |
| SCHEMBL25888999 | 0.73 | HSD11B1 (0.45) | HSD11B1TRPV1MALT1KMT2A | |
| SCHEMBL11962830 | 0.73 | HSD11B1 (0.45) | HSD11B1TRPV1MALT1KMT2A | |
| SCHEMBL10094610 | 0.73 | HSD11B1 (0.45) | HSD11B1TRPV1MALT1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110288129-A1 | AMIDE DERIVATIVES AS TRPV1 ANTAGONISTS | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | US | disclosed |
| US-7998982-B2 | Amide derivatives as TRPV1 antagonists | ABBOTT LABORATORIES (US) | 2011-08-16 | — | — | US | disclosed |
| EP-2185538-A2 | TETRAHYDROPYRIDINE CARBOXAMIDE DERIVATIVES AS TRPVL ANTAGONISTS | Abbott Laboratories (US) | 2010-05-19 | — | — | EP | disclosed |
| US-20090062345-A1 | AMIDE DERIVATIVES AS TRPV1 ANTAGONISTS | ABBOTT LABORATORIES (US) | 2009-03-05 | — | — | US | disclosed |
| WO-2009023539-A2 | TETRAHYDROPYRIDINE CARBOXAMIDE DERIVATIVES AS TRPVL ANTAGONISTS | ABBOTT LABORATORIES (US) | 2009-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062345-A1 | AMIDE DERIVATIVES AS TRPV1 ANTAGONISTS | TRPV1, TRPV3, TRPA1 | LMNA 3948/4885HSD11B1 3218/4885TRPV1 1/4885 |
| US-20110288129-A1 | AMIDE DERIVATIVES AS TRPV1 ANTAGONISTS | TRPV1, TRPV3, TRPA1 | LMNA 3948/4885HSD11B1 3218/4885TRPV1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.