Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.54 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.48 |
| ▸ | PARP1 | P09874 | 2/20 | 0.43 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | F13A1 | P00488 | 1/20 | 0.42 |
| ▸ | TGM2 | P21980 | 1/20 | 0.42 |
| ▸ | TGM1 | P22735 | 1/20 | 0.42 |
| ▸ | TGM3 | Q08188 | 1/20 | 0.42 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.42 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3436626 | 0.83 | HSD11B1 (0.48) | LMNAHSD11B1TRPV1PARP1TNK2 | |
| SCHEMBL11962834 | 0.82 | HSD11B1 (0.55) | HSD11B1TRPV1 | |
| SCHEMBL18228586 | 0.82 | HSD11B1 (0.55) | HSD11B1TRPV1 | |
| SCHEMBL15966094 | 0.82 | HSD11B1 (0.55) | HSD11B1TRPV1 | |
| SCHEMBL2614921 | 0.80 | CYP1A2 (0.56) | LMNAHSD11B1TRPV1 | |
| SCHEMBL13271105 | 0.80 | LMNA (0.56) | LMNAHSD11B1MALT1ELANE | |
| SCHEMBL8299219 | 0.79 | LMNA (0.59) | LMNAHSD11B1TRPV1MALT1 | |
| SCHEMBL2844754 | 0.79 | LMNA (0.59) | LMNAHSD11B1TRPV1 | |
| SCHEMBL5178342 | 0.79 | HSD11B1 (0.56) | HSD11B1TRPV1ELANE | |
| SCHEMBL1368883 | 0.79 | LMNA (0.47) | LMNAHSD11B1TRPV1MALT1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110288129-A1 | AMIDE DERIVATIVES AS TRPV1 ANTAGONISTS | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | US | disclosed |
| US-7998982-B2 | Amide derivatives as TRPV1 antagonists | ABBOTT LABORATORIES (US) | 2011-08-16 | — | — | US | disclosed |
| US-7964602-B2 | Biaryl compounds useful as agonists of the Gpr38 receptor | GLAXO GROUP LIMITED (GB) | 2011-06-21 | — | — | US | disclosed |
| CN-101801953-A | Tetrahydropyridyl carboxamide derivatives as TRPV1 antagonists | ABBOTT LAB | 2010-08-11 | — | — | CN | disclosed |
| EP-2185538-A2 | TETRAHYDROPYRIDINE CARBOXAMIDE DERIVATIVES AS TRPVL ANTAGONISTS | Abbott Laboratories (US) | 2010-05-19 | — | — | EP | disclosed |
| US-20090062345-A1 | AMIDE DERIVATIVES AS TRPV1 ANTAGONISTS | ABBOTT LABORATORIES (US) | 2009-03-05 | — | — | US | disclosed |
| WO-2009023539-A2 | TETRAHYDROPYRIDINE CARBOXAMIDE DERIVATIVES AS TRPVL ANTAGONISTS | ABBOTT LABORATORIES (US) | 2009-02-19 | — | — | WO | disclosed |
| US-20080306083-A1 | Biaryl Compounds Useful as Agonists of the Gpr38 Receptor | GLAXO GROUP LIMITED | 2008-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062345-A1 | AMIDE DERIVATIVES AS TRPV1 ANTAGONISTS | TRPV1, TRPV3, TRPA1 | LMNA 3948/4885HSD11B1 3218/4885TRPV1 1/4885 |
| US-20080306083-A1 | Biaryl Compounds Useful as Agonists of the Gpr38 Receptor | GPR88, GPR68, GPBAR1 | LMNA 3645/4885HSD11B1 789/4885TRPV1 159/4885 |
| US-20110288129-A1 | AMIDE DERIVATIVES AS TRPV1 ANTAGONISTS | TRPV1, TRPV3, TRPA1 | LMNA 3948/4885HSD11B1 3218/4885TRPV1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.