Sugi Predict

Sugi Predict / Compounds / SCHEMBL136954

SCHEMBL136954

SCHEMBL136954

CCOC(C)=C(CC)C(=O)O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 7/20 0.46
▸ LMNA P02545 1/20 0.46
▸ HSD17B10 Q99714 1/20 0.46
▸ SOAT1 P35610 1/20 0.44
▸ ALOX15 P16050 1/20 0.39
▸ MGAM O43451 1/20 0.39
▸ GAA P10253 1/20 0.39
▸ SI P14410 1/20 0.39
▸ MGAM2 Q2M2H8 1/20 0.39
▸ HCAR2 Q8TDS4 1/20 0.37
▸ TRPA1 O75762 1/20 0.36
▸ GLO1 Q04760 1/20 0.35
▸ FFAR3 O14843 1/20 0.35
▸ TDP1 Q9NUW8 1/20 0.35
▸ GRIK1 P39086 2/20 0.34
▸ CYP2D6 P10635 1/20 0.33
▸ TSHR P16473 1/20 0.33
▸ EGLN1 Q9GZT9 1/20 0.33
▸ THRB P10828 1/20 0.33
▸ FNTA P49354 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL136951 1.00 ALDH1A1 (0.46) ALDH1A1LMNAHSD17B10SOAT1ALOX15
SCHEMBL30422651 0.78 SOAT1 (0.46) ALDH1A1LMNAHSD17B10SOAT1ALOX15
SCHEMBL79926 0.78 SOAT1 (0.46) ALDH1A1LMNAHSD17B10SOAT1ALOX15
SCHEMBL29201836 0.77 ALDH1A1 (0.42) ALDH1A1LMNAHSD17B10SOAT1ALOX15
SCHEMBL28688125 0.77 ALDH1A1 (0.42) ALDH1A1LMNAHSD17B10SOAT1ALOX15
SCHEMBL29201842 0.77 ALDH1A1 (0.42) ALDH1A1LMNAHSD17B10SOAT1ALOX15
SCHEMBL4731227 0.77 OPRM1 (0.35) ALDH1A1LMNAHSD17B10SOAT1CYP2D6
SCHEMBL9739514 0.76 SOAT1 (0.44) ALDH1A1LMNAHSD17B10SOAT1ALOX15
SCHEMBL7770890 0.76 SOAT1 (0.44) ALDH1A1LMNAHSD17B10SOAT1ALOX15
SCHEMBL9739502 0.76 SOAT1 (0.44) ALDH1A1LMNAHSD17B10SOAT1ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2430029-B1 THIENO[2,3-B]PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS UNIV LEUVEN KATH (BE) 2018-01-10 — — EP disclosed
EP-2640729-B1 INHIBITORS OF HIV REPLICATION VIIV HEALTHCARE UK LTD (GB) 2016-12-21 — — EP disclosed
US-20160355528-A1 INHIBITORS OF HIV REPLICATION VIIV HEALTHCARE UK LIMITED (GB) 2016-12-08 — — US disclosed
US-9499563-B2 Thieno [2, 3-B] pyridine derivatives as viral replication inhibitors KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2016-11-22 — — US disclosed
US-9447116-B2 Inhibitors of HIV replication VIIV HEALTHCARE UK LIMITED (GB) 2016-09-20 — — US disclosed
US-20140315927-A1 Inhibitors of HIV Replication VIIV HEALTHCARE UK LIMITED (GB) 2014-10-23 — — US disclosed
US-20140296272-A1 THIENO [2, 3-B] PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS CISTIM LEUVEN VZW (BE) 2014-10-02 — — US disclosed
US-8809363-B2 Inhibitors of HIV replication VIIV HEALTHCARE UK LIMITED (GB) 2014-08-19 — — US disclosed
US-8785638-B2 Thieno [2, 3-B] pyridine derivatives as viral replication inhibitors KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2014-07-22 — — US disclosed
EP-2640729-A1 INHIBITORS OF HIV REPLICATION VIIV Healthcare UK Limited (GB) 2013-09-25 — — EP disclosed
EP-1286955-B1 ARYL AND HETEROARYLCYCLOPROPYL OXIME ETHERS AND THEIR USE AS FUNGICIDES DOW AGROSCIENCES LLC (US) 2005-02-02 — — EP disclosed
EP-1347952-A1 ARYL AND HETEROARYLCYCLOPROPYL OXIME ETHERS AND THEIR USE AS FUNGICIDES Dow AgroSciences LLC (US) 2003-10-01 — — EP disclosed
EP-1286955-A1 ARYL AND HETEROARYLCYCLOPROPYL OXIME ETHERS AND THEIR USE AS FUNGICIDES Dow AgroSciences LLC (US) 2003-03-05 — — EP disclosed
WO-2002046142-A1 ARYL AND HETEROARYLCYCLOPROPYL OXIME ETHERS AND THEIR USE AS FUNGICIDES DOW AGROSCIENCES LLC (US) 2002-06-13 — — WO disclosed
US-6348627-B1 CONTROLLING PHYTOPATHOGENIC FUNGI DOW AGROSCIENCES LLC 2002-02-19 — — US disclosed
WO-2001087826-A1 ARYL AND HETEROARYLCYCLOPROPYL OXIME ETHERS AND THEIR USE AS FUNGICIDES ROHM AND HAAS COMPANY (US) 2001-11-22 — — WO disclosed
US-6211195-B1 NERVOUS SYSTEM, PSYCHOLOGICAL AND GLANDULAR DISORDERS NEUROCRINE BIOSCIENCES, INC. 2001-04-03 — — US disclosed
EP-0977759-A1 CRF ANTAGONISTIC THIOPHENOPYRIDINES JANSSEN PHARMACEUTICA N.V. (BE) 2000-02-09 — — EP disclosed
WO-1998047903-A1 CRF ANTAGONISTIC THIOPHENOPYRIDINES JANSSEN PHARMACEUTICA N.V. (BE) 1998-10-29 — — WO disclosed
US-3998873-A ORGANOLEPTICS, PERFUMES, AROMAS INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) 1976-12-21 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160355528-A1 INHIBITORS OF HIV REPLICATION RTF2, POLRMT, MAVS ALDH1A1 4304/4885LMNA 3814/4885HSD17B10 2965/4885
US-20140296272-A1 THIENO [2, 3-B] PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS TYMP, DUT, MAVS ALDH1A1 1925/4885LMNA 3907/4885HSD17B10 3401/4885
US-20140315927-A1 Inhibitors of HIV Replication RTF2, POLRMT, MAVS ALDH1A1 4304/4885LMNA 3814/4885HSD17B10 2965/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.