Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | TSHR | P16473 | 4/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19526 | 0.86 | CYP1A2 (0.37) | SIGMAR1SLC6A2SLC6A3SLC6A4ADRA2B | |
| SCHEMBL194644 | 0.74 | CYP1A2 (0.53) | SIGMAR1SLC6A2SLC6A3SLC6A4CYP1A2 | |
| SCHEMBL2652667 | 0.74 | CYP1A2 (0.38) | SIGMAR1SLC6A2SLC6A3SLC6A4CYP1A2 | |
| SCHEMBL1715656 | 0.72 | SRR (0.40) | SIGMAR1SLC6A2SLC6A3SLC6A4CYP1A2 | |
| SCHEMBL10632921 | 0.71 | CYP1A2 (0.36) | SIGMAR1SLC6A2SLC6A3SLC6A4CYP1A2 | |
| SCHEMBL10793187 | 0.70 | CYP1A2 (0.35) | SIGMAR1SLC6A2SLC6A3SLC6A4CYP1A2 | |
| SCHEMBL27860489 | 0.70 | SLC6A2 (0.36) | SIGMAR1SLC6A2SLC6A3SLC6A4ADRA2B | |
| SCHEMBL29661913 | 0.66 | CNR2 (0.40) | OPRK1ALDH1A1TSHRKMT2ASMN1; SMN2 | |
| SCHEMBL11066730 | 0.66 | RCE1 (0.37) | SLC6A2SLC6A3SLC6A4CYP1A2ALDH1A1 | |
| SCHEMBL28056734 | 0.66 | CYP2C19 (0.38) | SLC6A2SLC6A3SLC6A4KCNH2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9290581-B2 | Immobilized proteins and methods and uses thereof | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2016-03-22 | — | — | US | disclosed |
| US-20140378670-A1 | Immobilized Proteins and Methods and Uses Thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2014-12-25 | — | — | US | disclosed |
| US-8916137-B2 | Monofunctional carbocyanine dyes for in vivo and in vitro imaging | THE GENERAL HOSPITAL CORPORATION (US) | 2014-12-23 | — | — | US | disclosed |
| US-20130137858-A1 | IMMOBILIZED PROTEINS AND METHODS AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2013-05-30 | — | — | US | disclosed |
| US-8188241-B2 | Immobilized proteins and methods and uses thereof | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2012-05-29 | — | — | US | disclosed |
| US-20110286933-A1 | MONOFUNCTIONAL CARBOCYANINE DYES FOR IN VIVO AND IN VITRO IMAGING | THE GENERAL HOSPITAL CORPORATION (US) | 2011-11-24 | — | — | US | disclosed |
| WO-2010054330-A2 | MONOFUNCTIONAL CARBOCYANINE DYES FOR IN VIVO AND IN VITRO IMAGING | THE GENERAL HOSPITAL CORPORATION (US) | 2010-05-14 | — | — | WO | disclosed |
| US-20100069607-A1 | METHOD OF COVALENTLY LINKING A CARBOHYDRATE OR POLYALKYLENE OXIDE TO A PEPTIDE, PRECURSORS FOR USE IN THE METHOD AND RESULTANT PRODUCTS | UCL BUSINESS PLC (GB) | 2010-03-18 | — | — | US | disclosed |
| US-20090069548-A1 | Immobilized Proteins and Methods and Uses Thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110286933-A1 | MONOFUNCTIONAL CARBOCYANINE DYES FOR IN VIVO AND IN VITRO IMAGING | MKI67, HCCS, PYCR1 | SIGMAR1 2279/4885SLC6A2 2052/4885SLC6A3 1416/4885 |
| US-20130137858-A1 | IMMOBILIZED PROTEINS AND METHODS AND USES THEREOF | STUB1, MARCKS, SUMO3 | SIGMAR1 3952/4885SLC6A2 4553/4885SLC6A3 3845/4885 |
| US-20140378670-A1 | Immobilized Proteins and Methods and Uses Thereof | STUB1, MARCKS, SUMO3 | SIGMAR1 3952/4885SLC6A2 4553/4885SLC6A3 3845/4885 |
| US-20100069607-A1 | METHOD OF COVALENTLY LINKING A CARBOHYDRATE OR POLYALKYLENE OXIDE TO A PEPTIDE, PRECURSORS FOR USE IN THE METHOD AND RESULTANT PRODUCTS | MSR1, C9, ADM2 | SIGMAR1 966/4885SLC6A2 4700/4885SLC6A3 4275/4885 |
| US-20090069548-A1 | Immobilized Proteins and Methods and Uses Thereof | STUB1, MARCKS, SUMO3 | SIGMAR1 3952/4885SLC6A2 4553/4885SLC6A3 3845/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.