Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13698456 | 0.72 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2KMT2APOLBDRD2 | |
| SCHEMBL13698426 | 0.72 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2KMT2APOLBKDM4E | |
| SCHEMBL13698420 | 0.72 | ALDH1A1 (0.57) | HSD11B1ALDH1A1SMN1; SMN2KMT2AHTR7 | |
| SCHEMBL13698453 | 0.71 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2DRD4DRD2SIGMAR1 | |
| SCHEMBL29998630 | 0.71 | HTR3E (0.70) | ALDH1A1SMN1; SMN2KMT2ADRD4HPGD | |
| SCHEMBL870704 | 0.71 | HTR3E (0.70) | ALDH1A1SMN1; SMN2KMT2ADRD4HPGD | |
| SCHEMBL13698436 | 0.71 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2HTR1AHTR2AHTR7 | |
| SCHEMBL3453846 | 0.69 | ALDH1A1 (0.54) | HSD11B1ALDH1A1SMN1; SMN2HTR7KDM4E | |
| SCHEMBL24163320 | 0.69 | KDM4E (0.46) | HSD11B1ALDH1A1SMN1; SMN2KMT2APOLB | |
| SCHEMBL13698437 | 0.67 | KMT2A (0.54) | HSD11B1ALDH1A1SMN1; SMN2KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090239873-A1 | Phenyl-piperazine derivatives as modulators of muscarinic receptors | BLANCO MIGUEL GARCIA-GUZMAN | 2009-09-24 | — | — | US | disclosed |
| US-7563795-B2 | Phenyl-piperazine derivatives as modulators of muscarinic receptors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239873-A1 | Phenyl-piperazine derivatives as modulators of muscarinic receptors | CHRM3, CHRM5, CHRM2 | HSD11B1 2896/4885ALDH1A1 2270/4885SMN1; SMN2 4374/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.