Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | LSS | P48449 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP4 | P49662 | 1/20 | 0.39 |
| ▸ | CASP5 | P51878 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25969216 | 0.88 | HSD11B1 (0.56) | KDM4EALDH1A1TRPV6MEN1KMT2A | |
| SCHEMBL28269086 | 0.74 | LSS (0.66) | KDM4EALDH1A1TRPV6MEN1KMT2A | |
| SCHEMBL1143256 | 0.73 | SIGMAR1 (0.60) | KDM4EALDH1A1MEN1KMT2AHSD11B1 | |
| SCHEMBL24162997 | 0.73 | KDM4E (0.51) | KDM4EALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL38659590 | 0.69 | KDM4E (0.58) | KDM4EALDH1A1TRPV6MEN1KMT2A | |
| SCHEMBL13698460 | 0.69 | HSD11B1 (0.47) | KDM4EALDH1A1MEN1KMT2AHSD11B1 | |
| SCHEMBL3994683 | 0.68 | HRH3 (0.67) | KDM4EALDH1A1LSSHPGDCASP1 | |
| SCHEMBL2056150 | 0.67 | MC4R (0.66) | KDM4EALDH1A1LSSHPGDCASP1 | |
| SCHEMBL1667217 | 0.67 | ALDH1A1 (0.63) | KDM4EALDH1A1TRPV6MEN1KMT2A | |
| SCHEMBL2208141 | 0.66 | HRH3 (0.71) | KDM4EALDH1A1MEN1KMT2ALSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022006518-A1 | COMPOUNDS AND METHODS OF PROMOTING OLIGODENDROCYTE PRECURSOR DIFFERENTIATION | THE CLEVELAND CLINIC FOUNDATION (US) | 2022-01-06 | — | — | WO | disclosed |