Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPE | Q05469 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 14/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 8/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 7/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 7/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11401289 | 0.77 | ALDH1A1 (0.55) | LIPELMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL640493 | 0.77 | LIPE (0.44) | LIPELMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL327691 | 0.70 | LIPE (0.40) | LIPELMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL12948008 | 0.70 | EPHX2 (0.46) | LIPELMNA | |
| SCHEMBL8750810 | 0.70 | DPP8 (0.60) | DPP4DPP8DPP9DPP7 | |
| SCHEMBL10899355 | 0.69 | ALDH1A1 (0.44) | LIPELMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL1800070 | 0.68 | CYP2C19 (0.46) | LIPEDPP8LMNAALDH1A1KMT2A | |
| SCHEMBL21568030 | 0.68 | LMNA (0.39) | LIPEDPP4DPP8DPP9DPP7 | |
| SCHEMBL10310589 | 0.67 | LIPE (0.40) | LIPELMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL24371198 | 0.66 | HSP90AA1 (0.39) | LIPEDPP8LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7572783-B2 | Obesity; N-(1-benzyl-piperidin-4-yl)-2-(2,5-dioxo-7-phenoxy-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl)-3-methyl-butyramide; modulators of ghrelin receptor (GHSR) | AMGEN INC. (US) | 2009-08-11 | — | — | US | disclosed |