Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acetohexamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | BLM | P54132 | 2/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.50 |
| ▸ | PPARG | P37231 | 3/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetohexamide SCHEMBL15669221 | 0.78 | ALDH1A1 (1.00) | LMNATSHRBLMTDP1ALDH1A1 | |
| Acetohexamide SCHEMBL37620 | 0.78 | ALDH1A1 (1.00) | LMNATSHRBLMTDP1ALDH1A1 | |
| Glymidine SCHEMBL34389 | 0.76 | TDP1 (0.56) | LMNATSHRTDP1ALDH1A1MAPT | |
| Glymidine SCHEMBL209818 | 0.75 | TDP1 (0.55) | LMNATSHRTDP1ALDH1A1MAPT | |
| Glymidine SCHEMBL27852481 | 0.75 | TDP1 (0.55) | LMNATSHRTDP1ALDH1A1MAPT | |
| SCHEMBL874584 | 0.73 | ADORA3 (0.74) | LMNATSHRBLMTDP1ALDH1A1 | |
| SCHEMBL4863686 | 0.72 | HRH3 (0.69) | LMNATSHRBLMTDP1ALDH1A1 | |
| SCHEMBL25258250 | 0.72 | ADORA3 (0.71) | LMNATSHRBLMTDP1ALDH1A1 | |
| Acetohexamide SCHEMBL14660013 | 0.68 | ALDH1A1 (0.72) | LMNATSHRBLMTDP1ALDH1A1 | |
| SCHEMBL5315570 | 0.67 | HDAC3 (0.68) | LMNAALDH1A1MEN1KMT2ALIMK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103717597-B | Heterocyclic compounds as kinase inhibitors | 原真股份有限公司 | 2017-07-04 | — | — | CN | disclosed |
| EP-2699579-A1 | PYRAZOLO [4, 3-D]PYRIMIDINES USEFUL AS KINASE INHIBITORS | Origenis GmbH (DE) | 2014-02-26 | — | — | EP | disclosed |
| EP-2699572-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | Origenis GmbH (DE) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012143143-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2012-10-26 | — | — | WO | disclosed |
| WO-2012143144-A1 | PYRAZOLO [4, 3-D] PYRIMIDINES USEFUL AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2012-10-26 | — | — | WO | disclosed |