Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KCNA3 | P22001 | 6/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | KCNA2 | P16389 | 1/20 | 0.33 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | NQO1 | P15559 | 1/20 | 0.32 |
| ▸ | POR | P16435 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13714431 | 0.76 | ALDH1A1 (0.40) | ALDH1A1KDM4ETSHRHSD17B10POLB | |
| SCHEMBL5519920 | 0.76 | KDM4E (0.40) | ALDH1A1KDM4ETSHRHSD17B10POLB | |
| SCHEMBL13725473 | 0.74 | KCNA3 (0.39) | ALDH1A1KDM4ETSHRHSD17B10PTPN1 | |
| SCHEMBL16345128 | 0.74 | KCNA3 (0.38) | ALDH1A1KDM4ETSHRHSD17B10POLB | |
| SCHEMBL18325951 | 0.70 | PTPN1 (0.34) | ALDH1A1KDM4ETSHRPOLBPTPN1 | |
| SCHEMBL17873619 | 0.69 | GABRA1 (0.55) | ALDH1A1KDM4ETSHRPOLBHPGD | |
| SCHEMBL23218838 | 0.68 | ALDH1A1 (0.42) | ALDH1A1KDM4ETSHRMAPK1MAPT | |
| SCHEMBL29853260 | 0.68 | ALDH1A1 (0.42) | ALDH1A1KDM4ETSHRMAPK1MAPT | |
| SCHEMBL23229000 | 0.68 | KCNA2 (0.37) | KCNA2KCNA1 | |
| SCHEMBL11539348 | 0.68 | PTPN1 (0.61) | ALDH1A1KDM4ETSHRPOLBPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7576098-B2 | Heterocyclic compounds as inhibitors of factor VIIa | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-08-18 | — | — | US | disclosed |
| EP-1828152-B1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF FACTOR VIIA | BRISTOL MYERS SQUIBB CO (US) | 2008-08-20 | — | — | EP | disclosed |
| US-7273886-B2 | For therapy and prophylaxis of clotting disorders; useful for inhibiting serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein | GENENTECH, INC. (US) | 2007-09-25 | — | — | US | disclosed |
| US-7273886-B2 | For therapy and prophylaxis of clotting disorders; useful for inhibiting serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein | GENENTECH, INC. (US) | 2007-09-25 | — | — | US | disclosed |
| US-7273886-B2 | For therapy and prophylaxis of clotting disorders; useful for inhibiting serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein | GENENTECH, INC. (US) | 2007-09-25 | — | — | US | disclosed |
| US-20070049601-A1 | BENZOFURAN INHIBITORS OF FACTOR VIIa | GENENTECH, INC. (US) | 2007-03-01 | — | — | US | disclosed |
| US-20070049601-A1 | BENZOFURAN INHIBITORS OF FACTOR VIIa | GENENTECH, INC. (US) | 2007-03-01 | — | — | US | disclosed |
| US-20070049601-A1 | BENZOFURAN INHIBITORS OF FACTOR VIIa | GENENTECH, INC. (US) | 2007-03-01 | — | — | US | disclosed |
| US-20060211720-A1 | Heterocyclic compounds as inhibitors of factor VIIa | BRISTOL-MYERS SQUIBB COMPANY | 2006-09-21 | — | — | US | disclosed |
| EP-1626966-A1 | BENZOFURAN INHIBITORS OF FACTOR VIIA | Genentech, Inc. (US) | 2006-02-22 | — | — | EP | disclosed |
| WO-2004113316-A1 | BENZOFURAN INHIBITORS OF FACTOR VIIA | GENENTECH, INC. (US) | 2004-12-29 | — | — | WO | disclosed |
| WO-2004113316-A1 | BENZOFURAN INHIBITORS OF FACTOR VIIA | GENENTECH, INC. (US) | 2004-12-29 | — | — | WO | disclosed |
| US-20040235852-A1 | Benzofuran inhibitors of factor VIIa | GENENTECH, INC. | 2004-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040235852-A1 | Benzofuran inhibitors of factor VIIa | TFPI, HABP2, SERPINE1 | ALDH1A1 604/4885KDM4E 1398/4885TSHR 3378/4885 |
| US-20070049601-A1 | BENZOFURAN INHIBITORS OF FACTOR VIIa | TFPI, HABP2, F7 | ALDH1A1 941/4885KDM4E 1225/4885TSHR 3289/4885 |
| US-20060211720-A1 | Heterocyclic compounds as inhibitors of factor VIIa | TFPI, F7, HABP2 | ALDH1A1 3937/4885KDM4E 631/4885TSHR 3311/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.