Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.71 |
| ▸ | YAP1 | P46937 | 1/20 | 0.43 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.43 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.40 |
| ▸ | MPO | P05164 | 5/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Etofenamate SCHEMBL28086507 | 1.00 | LMNA (0.71) | LMNACYP1A2CYP2C9CYP2C19YAP1 | |
| Etofenamate SCHEMBL25152 | 0.84 | LMNA (1.00) | LMNACYP1A2CYP2C9CYP2C19YAP1 | |
| Etofenamate SCHEMBL6836167 | 0.82 | LMNA (0.92) | LMNACYP1A2CYP2C9CYP2C19YAP1 | |
| SCHEMBL12715082 | 0.80 | LMNA (0.91) | LMNACYP1A2CYP2C9CYP2C19YAP1 | |
| SCHEMBL10631533 | 0.74 | LMNA (0.78) | LMNACYP1A2CYP2C9CYP2C19YAP1 | |
| Ufenamate SCHEMBL29376700 | 0.72 | CYP1A2 (0.72) | LMNACYP1A2CYP2C9CYP2C19YAP1 | |
| Ufenamate SCHEMBL36095 | 0.72 | CYP1A2 (0.72) | LMNACYP1A2CYP2C9CYP2C19YAP1 | |
| SCHEMBL10597386 | 0.72 | LMNA (0.71) | LMNACYP1A2CYP2C9CYP2C19YAP1 | |
| SCHEMBL3812938 | 0.71 | LMNA (0.70) | LMNACYP1A2CYP2C9CYP2C19YAP1 | |
| Etofenamate SCHEMBL28772901 | 0.71 | LMNA (0.69) | LMNACYP1A2CYP2C9CYP2C19YAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699579-A1 | PYRAZOLO [4, 3-D]PYRIMIDINES USEFUL AS KINASE INHIBITORS | Origenis GmbH (DE) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012143144-A1 | PYRAZOLO [4, 3-D] PYRIMIDINES USEFUL AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2012-10-26 | — | — | WO | disclosed |