Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13733486 | 1.00 | HSD17B10 (0.37) | HSD17B10SIGMAR1PTGDR2DRD2DRD3 | |
| SCHEMBL28068816 | 0.80 | SIGMAR1 (0.33) | SIGMAR1PTGDR2DRD2DRD3SMN1; SMN2 | |
| SCHEMBL16400400 | 0.80 | SIGMAR1 (0.33) | SIGMAR1PTGDR2DRD2DRD3SMN1; SMN2 | |
| SCHEMBL18691907 | 0.80 | HSD11B1 (0.43) | SIGMAR1DRD2DRD3SMN1; SMN2MAPT | |
| SCHEMBL13662624 | 0.80 | P2RX7 (0.42) | PTGDR2DRD2DRD3SMN1; SMN2 | |
| SCHEMBL22117940 | 0.80 | MAPK1 (0.50) | PTGDR2DRD2DRD3SMN1; SMN2MAPT | |
| SCHEMBL3462061 | 0.80 | MAPK1 (0.50) | PTGDR2DRD2DRD3SMN1; SMN2MAPT | |
| SCHEMBL21772146 | 0.80 | MAPK1 (0.50) | PTGDR2DRD2DRD3SMN1; SMN2MAPT | |
| SCHEMBL16660369 | 0.79 | SLC6A9 (0.53) | HSD17B10SIGMAR1SLC6A9 | |
| SCHEMBL2290670 | 0.79 | SLC6A9 (0.53) | HSD17B10SIGMAR1SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699562-A1 | BICYCLIC HETEROCYCLE COMPOUNDS AND THEIR USES IN THERAPY | Astex Therapeutics Limited (GB) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012143726-A1 | BICYCLIC HETEROCYCLE COMPOUNDS AND THEIR USES IN THERAPY | ASTEX THERAPEUTICS LIMITED (GB) | 2012-10-26 | — | — | WO | disclosed |