Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | CCR6 | P51684 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28237972 | 0.79 | MAPT (0.47) | HSD17B10TSHRSMN1; SMN2TDP1MAPT | |
| SCHEMBL25422711 | 0.76 | TDP1 (0.42) | TSHRTDP1MAPTHTTNPSR1 | |
| SCHEMBL28267575 | 0.76 | HSD17B10 (0.43) | HSD17B10TSHRSMN1; SMN2TDP1MAPT | |
| SCHEMBL15591482 | 0.71 | MAPT (0.44) | HSD17B10TSHRSMN1; SMN2TDP1MAPT | |
| SCHEMBL348022 | 0.68 | — | — | |
| SCHEMBL772362 | 0.67 | TSHR (0.58) | HSD17B10TSHRSMN1; SMN2TDP1MAPT | |
| SCHEMBL8053279 | 0.67 | TSHR (0.58) | HSD17B10TSHRSMN1; SMN2TDP1MAPT | |
| SCHEMBL30313522 | 0.67 | TSHR (0.58) | HSD17B10TSHRSMN1; SMN2TDP1MAPT | |
| SCHEMBL2760410 | 0.67 | MAPT (0.47) | SMN1; SMN2TDP1MAPTHTTNPSR1 | |
| SCHEMBL4492163 | 0.66 | CTSD (0.54) | SMN1; SMN2TDP1MAPTHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090215814-A1 | Method of inhibiting neurotrophin-receptor binding | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2009-08-27 | — | — | US | disclosed |
| US-20080221147-A1 | Method of inhibiting neurotrophin-receptor binding | ROSS GREGORY M | 2008-09-11 | — | — | US | disclosed |
| US-20070078137-A1 | Method of inhibiting neurotrophin-receptor binding | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2007-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215814-A1 | Method of inhibiting neurotrophin-receptor binding | NGF, NTRK2, BDNF | HSD17B10 4411/4885TSHR 342/4885SMN1; SMN2 707/4885 |
| US-20080221147-A1 | Method of inhibiting neurotrophin-receptor binding | NGF, NTRK2, BDNF | HSD17B10 4411/4885TSHR 342/4885SMN1; SMN2 707/4885 |
| US-20070078137-A1 | Method of inhibiting neurotrophin-receptor binding | NGF, NTRK2, BDNF | HSD17B10 4411/4885TSHR 342/4885SMN1; SMN2 707/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.